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尼卡地平和硝普钠治疗高血压急症的价值比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第3期
页码:
244-246
栏目:
临床研究
出版日期:
2004-05-01

文章信息/Info

Title:
Comparison between intravenous nicardipine and sodium nitroprusside in hypertensive emergency
作者:
高晖命; 何争; 刘红娟
第四军医大学西京医院心血管内科，陕西 西安 710032
Author(s):
GAO Hui; HE Zheng; LIU Hong-Juan
Department of Cardiology，Xijing Hospital，Fourth Military Medical University，Xi'an，Shaanxi 710032，China
关键词:
高血压; 尼卡地平; 硝普钠; 率压积
Keywords:
hypertension;  nicardipine;  nitroprusside;  rate-pressure product
分类号:
R544.11
DOI:
-
文献标识码:
A
摘要:
目的:比较静滴尼卡地平和硝普钠治疗急症高血压的打效和安全性。方法:急症高血压(非危急症高血压)患者92例随机分为2组。尼卡地平组(47例)静滴尼卡地平30 mg，以0.6 μg·k g-1·min-1滴速开始，每隔5 min根据患者血压调节滴速，直至达到目标血压后维持该滴速，最大剂量不超过6 μg·k g-1·min-1;硝普钠组45例静滴硝普钠25 mg，以0.5 μg·k g-1·min-1滴速开始，每隔5 min以0.5-1.5 μg·k g-1·min-1滴速递增，直至达到目标血压后维持静滴，最大剂量不超过10 μg·k g-1·min-1。结果:尼卡地平组SBP从治疗前的184±22 mmHg降至用药结束时125±9 mmHg (P0.05 ).结论:静脉应用尼卡地平与硝普钠降压疗效相近，不良反应发生率低，可用于非危急症的重度高血压患者的治疗。
Abstract:
AIM:To compare the efficacy and safety of intravenous nicardipine with sodium in urgency of hypertension. METHODS:92 patients with severe hypertension were randomized into two groups. Intravenous nicardipine was given at an initial rate of 0.6 μg·kg-1·min-1，then the rate was adjusted every 5 minutes until the objective blood pressure was obtained in the group of nicardipine (n=47). The maximum dose was no more than 6 μg·kg-1·min-1. Intravenous nitroprusside was give at increasing rates from 0.5 to 10 μg·kg-1·min-1 that was titrated on the basis of the objective blood pressure in the group of nitroprusside (n=45). RESULTS:After the therapy，SBP and DBP decreased obviously from 184±22 and 106±18 mm Hg to 125±9 and 80±6 mmHg respectively in the group of nicardipine (P<0. 01);SBP and DBP descended markedly from 183±21 and 105±17 mmHg to 129±9 and 83±4 mm Hg in the group of nitroprusside (P<0. 01).Compared with those of pretherapy，the rate-pressure products were regressed significantly in both groups (P<0. 01).Adverse effects were observed in 4/47(900)and 8/45 (17%)，respectively (NS). CONCLUSION :Intravenous nicardipine is not only as effective as nitroprusside，but also safe in the therapy of severe hypertensive emergency.

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备注/Memo

备注/Memo:
收稿日期：2004-1-19
更新日期/Last Update: 2004-05-01