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卡托普利对心绞痛患者流变学和心肌缺血的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第4期
页码:
346-348
栏目:
临床研究
出版日期:
2004-07-01

文章信息/Info

Title:
Effects on hemorheologic change and myocardial ischemia of angina pectoris patients with Captopril
作者:
贾如意; 岳文伟; 孙海玲; 姜捷; 虞华鹤; 贾银红
济南市第四人民医院心内科，济南市心血管病研究所，山东 济南 250031
Author(s):
JIA Ru-yi; YUE Wen-wei; SUN Hai-ling; JIANG Jie; YU Hua-peng; JIA Yin-bong
Division of Cardiology,The Fourth People's Hospital of Jinan Jinan Research Institute of Cardiovascular Diseases, Ji nan,Shandong 250031,China
关键词:
高血压; 高岛胰素血症; 胰岛素抵杭
Keywords:
Captopril; angin apectoris; hemorheology
分类号:
R541-4
DOI:
-
文献标识码:
A
摘要:
目的:观察卡托普利对心绞痛患者血流变各项指标和心肌缺血发作的影响.方法:51例心绞痛患者随机分为卡托普利组和对照组，观察患者血流变各项指标和心绞痛患者心肌缺血发作的情况.结果:卡托普利能显著降低心绞痛患者高、低切变率时的全血枯度，全血高、低切还原粘度.卡托普利能明显改善心绞痛患者红细胞的变形性、心绞痛程度显著降低、心绞痛持续时间显著缩短.卡托普利对心绞痛患者血浆粘度、红细胞压积、纤维蛋白原、血压、 血糖均无明显影响.结论:卡托普利能显著降低血液粘度，改善心绞痛患者红细胞的变形性、显著降低心绞痛程度、心绞痛持续时间显著缩短，有利于改善微循环灌注，改善心脏供血、供权，有利于预防动脉血栓形成和降低急性心肌梗死的发病率。
Abstract:
AIM:To observe the effects of Captopril on the markers of hemorheologic change,blood goucose，blood pressure，and episode of angina. METHODS:Fifty-one angina pectoris patients were randomized divided into Captopril treatment group and control group,to observe the effects of Captopril on the markers of blood stream change,blood glucose,blood pressure,and episode of angina. RESULTS:The blood viscosity and reductive blood viscosity were decreaesed significantly for the patients treated with Captopril. After treatment with Captopril,the deformability of erythrocytea meliorated significantly,the degree of angina decreased remarkably,the episode of angina shortened significantly. Compared with the control group,there were no significant difference for the plasma viscosity,fibrinogen,ratio volume of erythrocyte，blood glucose and blood pressure. CONCLUSION: Captopril can significantly reduce blood viscosity,ameliorate the deformability of erythrocyte,decrease the degree of angina,shorten the episode of angina.It is advantageous to ameliorate micro-circulation,to suppply blood and exygen for heart 9 to prevent artery thrombosis, and to reduce the incidence of acute myocardial infarction.

参考文献/References

[1] The Heart Outcomes Prevention Evaluation Study Investigators. Effects of anangiotensin-converting enzyme inhibition, ramipril,on death from cardiovascular causes,myocardial infarction,and stroke in high-risk patients[J].N Engl J Med,2000,342: 145-153.

[2] 中华医学会心血管病学分会，中华心血管病杂志编辑委员会，中国循环杂志编辑委员会.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志，2001,29(12):710-725.

[3] 徐秀英，白丹，汪家瑞.血管紧张素I对大鼠主动脉PAI-1,tPA活性的影响及不同肾素活性状态下纤溶功能的变化[J].心脏杂志，2002,14(1):45-51.

[4] 贾如意，李志善，姚伟东，等.卡托普利对大鼠t-PA和PAM活性的作用[J].中国现代应用药学杂志，2001,18(1):20-21.

[5] Hoshida S,Kato J,Nishino M,et al. Increased angiotensin-convert in genzymea ctivity in coronary artery specimens from patients with acute coronary syndrome[J].Circulation,2001,103:630-633.

[6] Lonn EM,Dphil SYM,Dzavik V,et al. Effects of ramipril and vitamin E on atherosclerosis:the study to evaluate carotidul trasound changes in patients treated with ramipril and vitamin E(SECURE)[J].Circulation,2001,103:919-925.

备注/Memo

备注/Memo:
收稿日期：2003-7-28
更新日期/Last Update: 2004-07-01