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U50 ,488H 对大鼠肺动脉的舒张作用及机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
513-516
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
Vasorelaxing effect of U50 ,488Hon pulmonary artery in rats and underlying mechanism
作者:
孙　新; 臧益民; 王跃民; 毕　辉; 槐　勇; 马　恒; 裴建明
第四军医大学生理学教研室,陕西西安710032
Author(s):
SUN Xin ;  ZANG Yi-min ;  WANG Yue-min ;  BI Hui ;  HUAI Yong ;  MA Heng ;  PEI Jian-ming
Department of Physiology , Fourth Military Medical University , Xi’an ,Shaanxi 710032 , China
关键词:
κ阿片受体; U50 ; 488H; 肺动脉; 内皮细胞; 一氧化氮
Keywords:
κ-opioid receptor ;  U50 ; 488H; pulmonary artery ; endothelium ;  nit ric oxide
分类号:
R332. 2
DOI:
-
文献标识码:
A
摘要:
目的:观察κ阿片受体选择性激动剂U50 ,488H对大鼠肺动脉的舒张作用并探讨其机制。方法:分离正常大鼠肺动脉,采用离体血管灌流实验,观察U50 ,488H对大鼠肺动脉血管环舒缩功能的影响。结果: ①U50 ,488H 在30～140μmol/ L 范围内对大鼠肺动脉呈现明显的剂量依赖性舒张效应,该作用可被κ阿片受体选择性阻滞剂norBNI 所阻断; ②经去内皮处理后,U50 ,488H对肺动脉的舒张效应显著减弱; ③预先用NO 合成酶抑制剂左旋硝基 精氨酸甲酯(L-NAME) 处理可显著降低U50 ,488H对肺动脉的舒血管效应; 而β受体阻断剂心得安、M 受体阻断剂(阿托品) 、KATP通道阻断剂(优降糖) 、前列腺素合成抑制剂(消炎痛) 等对U50 ,488H 舒张肺动脉的作用无明显影响。结论:本研究首次证明κ阿片受体激动剂U50 ,488H可内皮依赖性地舒张大鼠肺动脉,其舒张肺动脉的效应可能与NO 途径有关。
Abstract:
AIM: To investigate the relaxation effect and underlying mechanism of U50 ,488H (a selectiveκ-opioid receptor agonist) on pulmonary artery in the rat . METHODS : Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. RESULTS : U50 ,488H at 30～140 μmol/ L relaxed the pulmonary artery ring in a dose-dependent manner ; The relaxation effect of U50 ,488H on pulmonary artery was partially endothelium-dependent ; The relaxation effect of U50 ,488H was significantly attenuated in the presence of L-NAME and was not changed by glybenclamide , indomethacin , at ropine and propranalol. CONCLUSION: U50 ,488H is an endothelium-dependent vasodilator , it relaxes the pulmonary artery via nit ric oxide (NO)-dependent pathway in the rat .

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-9-5
更新日期/Last Update: 2004-11-01