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已酮可可碱对球囊损伤后血管胶原增生及狭窄的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
530-531,534
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
The influence of pentoxifyll ine on the collagen hyperplasia in balloon injury arteries
作者:
曾欣1; 王伟1; 曾哲2
1. 汕头大学医学院第一附属医院心内科,2. 汕头大学医学院第二附属医院心内科,广东汕头515000
Author(s):
ZENG Xin1; WANG Wei1; ZENG Zhe2
1. Department of Cardiology ,First Affiliated Hospital of Medical College of Shantou University , 2.Department of Cardiology ,Second Affiliated Hospital of Medical College of Shantou University , Shan-tou ,Guangdong ,515000 ,China
关键词:
胶原; 内膜; 再狭窄; 血管成形术; 已酮可可碱
Keywords:
collagen ;  neointima ;  angioplasty ;  pentoxifylline
分类号:
R961
DOI:
-
文献标识码:
A
摘要:
目的:探讨己酮可可碱(PTX) 对实验性兔髂动脉球囊成形术后狭窄的干预作用。方法:新西兰大耳白兔40只,建立髂动脉球囊损伤后狭窄模型,随机分成用药组与空白对照组,每组20 只,于血管成形术后4 周处死各组动物,取目标血管段用计算机图像分析检测血管管腔面积、新生内膜面积、胶原特殊染色平均灰度值。结果:用药组与空白对照组的内膜胶原染色平均灰度分别为18. 6 ±4. 6 和29. 3 ±5. 7 ( P < 0. 01) ;两组血管管腔面积差异显著,(1. 10 ±0. 23 vs 0. 84 ±0. 19 , P < 0. 05) ;用药组较空白对照组的新生内膜面积减少(0. 64 ±0. 07 vs 0. 89 ±0. 26 , P< 0. 01) 。结论:PTX能显著抑制内膜胶原的沉积,增大管腔面积,从而减轻血管损伤修复时再狭窄的程度。
Abstract:
AIM : To study the effect of pentoxifylline (PTX) on collagen hyperplasia of rabbit iliac arteries after balloon overst rech injury. METHODS: Forty adult male rabbit s were divided into two groups at random : ① the balloon group ( n = 20) that received only the balloon injury , ②The PTX group ( n = 20) that were int raperitoneally irrigated of PTX at a dose of 42 mg/ kg f rom 1 day before the injury till the animals were harvested after 4 weeks later. The illac arteries were analyzed by cross- sectional morphomet ry and the lumen area (LA) and neointimal area (NA) were calculated. The mean greym of collagen within the neointima were also examined by Van Gieson stain to look into collagen production. RESULTS: The collagen greym of neointima in the PTX group was prominently different f rom in the that balloon group (18. 6. 46 ±4. 56 vs 29. 3 ±5. 71 , P < 0. 01) . The LA of the PTX group was 1. 10 ±0. 23 mm2 and that of the balloon group was 0. 84 ±0. 19 mm2 ( P < 0. 05) . The NA of the PTX group was significantly lower than that of the balloon group (0. 64 ±0. 07 mm2 vs 0. 89 ±0. 26 mm2 ; P < 0. 01) . CONCLUSION:PTX may pretect the artery f rom stenosis by weakening collagen production and improving the lumen area after the balloon injury.

参考文献/References

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[5 ] 安群星,刘利兵,程晓东,等. 己酮可可碱对内毒素血症大鼠心肌组织TNF-α基因表达的影响[J ] . 心脏杂志,2003 ,15 (3) :156 - 158.

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备注/Memo

备注/Memo:
收稿日期：2004-5-16
更新日期/Last Update: 2004-11-01