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低硒与大鼠心肌组织脂质过氧化及心肌细胞损伤的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
532-534
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
The relationship between low blood seleniumand l ipid peroxidize and damages of rats’myocardium
作者:
张超英1; 党寅虎1; 王辉2; 苏宝山1
西安交通大学第二医院:1. 心内科;2. 干部病房;3. 病理科, 陕西西安710004
Author(s):
ZHANG Chao-ying1; DANG Yin-hu1; WANG Hai2; SU Bao-shan3
1. Department of Cardiology ,Second Hospital ,Xi′an J iaotong University ,Xi′an ,Shaanxi 710004
关键词:
硒; 脂质过氧化物; 心肌损伤
Keywords:
selenium ;  lipid peroxidize ;  myocardial damage
分类号:
R542. 22
DOI:
-
文献标识码:
A
摘要:
目的:观察低硒喂养对大鼠心肌组织脂质过氧化物、心肌细胞超微结构及细胞凋亡的影响。方法:将SD 大鼠分为低硒饲料喂养及低硒饲料加硒喂养两组,至12 周时测血硒、谷胱甘肽过氧化物酶( GPX) 、心肌组织匀浆丙二醛(MDA) 水平,行心肌组织超微结构电镜观察及心肌细胞凋亡检测。结果:低硒喂养组大鼠血硒及GPX 水平较加硒喂养组显著为低,心肌组织匀浆MDA 水平显著升高,心肌细胞线粒体肿胀增大,线粒体嵴排列紊乱,部分嵴溶解,部分线粒体空泡变,心肌细胞凋亡发生率显著升高。结论:低硒可致心肌过氧化物损伤、心肌细胞线粒体损伤及细胞凋亡。
Abstract:
AIM: To investigate the effect s of low-selenium diet on rat s′myocardial lipid peroxidize and apoptosis. METHODS: The rat s were divided into two groups , fed with low2selenium diet and sufficient selenium diet for 12 weeks. Then , the levels of blood selenium , glutathione peroxidase ( GPX) ,malondialdehyde (MDA) in myocardium in both groups were measured , and the two groups of rat s’myocardial ult rast ructure and apoptosis were observed respectively. RESULTS: The levels of blood selenium , GPX in rat s fed with low-selenium diet in much lower than those in sufficient selenium diet ,the level MDA in myocardium was significantly higher in low-selenium diet group , and the myocardial ult rast ructure were changed markedly in rat s fed with low-selenium diet , and the rate of myocardial apoptosis was much higher in that group as well. CONCLUSION: Low activity of GPX resulted f rom lacking of selenium and the secondary damage caused by lipid peroxidize may associate with the development of mitochondria damage and apoptosis in cardiac myocytes.

参考文献/References

[1] 徐光禄. 亚硒酸钠预防克山病以及缺硒与克山病病因的关系[J ] . 西安医科大学学报,1987 ,8 (3) :329.

[2 ] 梯保雄,韩福生,于维汉. 蛋白质对饲克山病病区粮大鼠心肌损伤的保护作用[J ] . 中国地方病学杂志,2002 ,21 (4) :245 - 247.

[3 ] Bermano G, Arthur JR , Hesketh J E. Role of the 3’untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase gene expression by selenium supply [J ] . Biochem J , 1996 , 320 ( Pt 3) : 891 - 895.

[ 4 ] Toyoda H , Himeno S , Imura N. The regulation of glutathione peroxidase gene expression relevant to species difference and the effects of dietary selenium manipulation [ J ] . Biochim Biophys Acta ,1989 , 1008 (3) : 301 - 308.

[ 5 ] Lei XG, Evenson J K, Thompson KM , et al . Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are different - tially regulated in rats by dietary selenium[J ] . J N ut r ,1995 , 125 (6) : 1438 - 1446.

[ 6 ] 张　博,裴建明,高　峰. 一氧化氮在心脏细胞凋亡中的作用 [J ] . 心脏杂志,2003 ,15 (1) :61 - 66.

备注/Memo

备注/Memo:
收稿日期：2004-9-3
更新日期/Last Update: 2004-11-01