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nCPAP治疗SAS 的效果及对血压和血管活性物质的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
34-36
栏目:
临床研究
出版日期:
2005-01-05

文章信息/Info

Title:
The effects of nCPAP on blood pressure and vasoactive substances in patients with SAS
作者:
张丙芳1; 谢文1; 范风云2; 薛 军1; 戚好文1
第四军医大学西京医院 1.呼吸内科， 2.放疗科，陕西 西安 710032
Author(s):
ZHANG Bingfang1;  XIE Wen1;  FAN Fengyun2;  XUE Jun1; QI Haowen1
1. Department of Respiratory Medicine, 2. Department of Radiotherapy ,Xijing Hospital, Fourth Military Medical University, Xian， Shaanxi 710032,China
关键词:
睡眠呼吸暂停综合征; 持续气道正压通气; 血压; 血管活性物质
Keywords:
sleep apena syndrome;  continuous positive airway pressure;  blood pressure;  vasoactive substance
分类号:
R563.8
DOI:
-
文献标识码:
A
摘要:
目的 探讨经鼻持续气道正压（nCPAP）治疗睡眠呼吸暂停综合征（SAS）的效果及对血压和血管活性物质的影响。方法 经多导睡眠图（PSG）确诊的SAS患者30例给予nCPAP治疗，同时记录夜间平均动脉血压（MAP）和动脉血氧饱和度（SaO2），放免法测定nCPAP治疗前后血浆中内皮素（ET）、血管紧张素Ⅱ（AngⅡ）、心房钠尿肽（ANP）和降钙素基因相关肽（CGRP）浓度的变化。结果 ①nCPAP治疗后SAS患者的睡眠结构和呼吸暂停低通气指数（AHI）显著改善，SaO2显著提高（P<0.01）；②nCPAP治疗后MAP显著降低（P<0.05），血浆中ET、AngⅡ、ANP也显著降低（P<0.01，P<0.05），而CGRP显著升高（P<0.05）。结论 nCPAP治疗SAS效果显著，SAS患者MAP的改善可能与血浆中血管活性物质发生恢复性变化有关。
Abstract:
AIM To explore the role of nasal continues positive airway pressure (nCPAP)on blood pressure and vasoactive substances in patients with sleep apnea syndrome (SAS). METHODS 30 SAS patients who were confirmed by polysomnography (PSG) were treated by nCPAP. Meanwhile the night mean artery pressure (MAP) and arterial O2 saturation (SaO2)were recorted by PSG and the plasma levels of endothelin (ET), AngiotensionⅡ(AngⅡ), atrial natriuretic peptide (ANP)and calcitonin generelated peptide (CGRP) were measured by radioimmunoassay and compared before and after one night nCPAP treatment. RESULTS ①After nCPAP treatment, improvement of sleep composition and decrease in apena/hypopnea index (AHI) and significant increase in SaO2 （P<0.01）during sleep were recorded by PSG. ②After nCPAP treatment, the levels of MAP and plasma ET, AngⅡ, ANP significantly decresed in patients with SAS（P<0.05，P<0.01),but the plasma level of CGRP significantly increased in SAS patients. CONCLUTION The effect of nCPAP treatment was definite for patients with SAS. The improvenment of night MAP in SAS patients may relate to the return of plasma vasoactive substances.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2003-12-15.
更新日期/Last Update: 2010-01-05