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ATP敏感性钾通道在缺血预适应中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
83-86
栏目:
综述
出版日期:
2005-01-05

文章信息/Info

Title:
-
作者:
周逸 综述; 唐其柱 审校
武汉大学人民医院心血管内科，湖北 武汉 430060
Author(s):
-
关键词:
ATP敏感性钾通道; 心肌; 缺血预适应
Keywords:
-
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
缺血预适应对心肌缺血/再灌注损伤有一定的保护作用，而ATP敏感性钾通道(KATP)是缺血预适应的重要环节。KATP开放剂可以产生预适应样心肌保护作用，KATP阻断剂能取消缺血预适应的保护作用。但KATP介导缺血预适应的作用位点是在心肌细胞膜还是在线粒体尚有争议。作者就KATP的结构，功能和在缺血预适应中的作用与机制作一综述。
Abstract:
-

参考文献/References

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［11］Wang Y, Takashi E, Xu M, et al. Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide［J］. Circulation, 2001, 104(1): 85-90.

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备注/Memo

备注/Memo:
收稿日期：2004-03-06.
更新日期/Last Update: 2010-01-05