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转化生长因子β1在扩张型心肌病大鼠心肌纤维化中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第2期
页码:
126-128
栏目:
基础研究
出版日期:
2005-03-05

文章信息/Info

Title:
he role of transforming growth factor β1 in left ventricular myofibrosis in rats with furazolidoneinduced dilated cardiomyopathy
作者:
黄荣杰1;  刘唐威2;  庞玉生3
1.广西医科大学第二附属医院ICU，2.广西心血管病研究所，3.广西医科大学第一附属医院儿科，广西 南宁 530007
Author(s):
HANG Rongjie1;  LIU Tangwei2; PANG Yusheng3
1. Department of ICU, Second Hospital, Guangxi Medical University, Nanning，Guangxi 530007,China
关键词:
转化生长因子β1; 呋喃唑酮; 扩张型心肌病; 心肌纤维化
Keywords:
transforming growth factor β1 ; furazolidone; dilated cardiomyopathy; myofibrosis
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 探讨转化生长因子（TGF）β1在扩张型心肌病大鼠左室心肌纤维化过程中的作用。方法 用呋喃唑酮饲养Wistar大鼠建立扩张型心肌病大鼠模型, 超声心动图检测大鼠心功能，病理学测量大鼠左室内径和左室游离壁厚度，HE和VG染色分别观察大鼠心肌细胞和间质胶原纤维的变化，免疫组化检测左室心肌组织TGF β1表达水平。结果 扩张型心肌病大鼠左心室内径增大、游离壁变薄, 左室收缩功能下降；心肌细胞肥大、变性，核增大、分裂、畸形；间质胶原纤维明显增生；左室心肌组织TGF β1表达水平明显增高。结论 TGF β1在扩张型心肌病大鼠左室心肌纤维化中起重要作用。
Abstract:
AIM To study the action of transforming growth factor (TGF) β1 in rats myofibrosis with furazolidone induced dilated cardiomyopathy. METHODS The Wistar rat model of dilated cardiomyopathy was created by fed with Furazolidone .The cardiac funtion of rats was detected by echocardiography. Left ventricular interior diameter and the thickness of ventricular free wall were measured afrer the rats were killed. Myocardial cell morphology and interstitial collagen were observed by HE and VG stain. TGF β1 was detected by immunohistochemical method. RESULTS The left ventricular interior diameter became wide and the thickness of ventricular free wall was thin. The left ventricular contract function decreased significantly. Cardiac myocyte hypertrophy and lysis accompanied with nucleus augmentation, differetiation and aberration. The level of TGF β1 was increasesd. All were seen in the rat with dilated cardiomyopathy. CONCLUSION TGF β1 is the main role of left ventricular myofibrosis in rats with furazolidoneinduced dilated cardiomyopathy.

参考文献/References

［1］ 罗惠兰，何作云，冯兵,等. 碱性成纤维细胞生长因子和转化生长因子β1 表达与心肌肥大的研究［J］.临床心血管病杂志，2001，17（2）：83-84.

［2］Concepcion L, Nerea V, Javier D. Transforming growth factor? in hypertensives with cardiorenal damage［J］. Hypertension, 2000, 36: 517-522.

［3］王晓红，贾国良，张清，等. PTCA术前后患者TNF,TGF和PGF水平分析［J］.心脏杂志，2002，14（7）：136-138.

［4］Sanderson JE, Lai KB, Shum IOL, et al. Transforming growth factorβ1 expression in dilated cardiomyopathy［J］. Heart， 2001，86:701-708.

备注/Memo

备注/Memo:
收稿日期：2004-07-06.
更新日期/Last Update: 2010-01-05