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L-精氨酸对急性心肌梗死患者心功能和心律失常的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第2期
页码:
135-136
栏目:
临床研究
出版日期:
2005-03-05

文章信息/Info

Title:
The effect of LArg on cardiac function and arrhythmia of patients with AMI
作者:
张锁龙1;  蒋益民2; 王俊2; 汪勤2;  高艳珍2
1. 横店集团医院内科，浙江 东阳 322118；2. 江苏大学医学院附属第四人民医院，江苏 镇江 212001
Author(s):
ZHANG Suolong1;  JIANG Yimin2;  WANG Jun2;  WANG Qin2; GAO Yanzheng2
1.Deparment of Cardiology, Hengdian Group Hospital,dongyang, Zhejiang 322118 ,China
关键词:
精氨酸; 左旋; 心肌梗塞; 急性; 超声心动描记术; 心功能; 心律失常
Keywords:
Larginine; myocardiac infarction; acute;  echocardiography;  ventricular function;  ventricular arrhythmia
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 观察内皮衍生舒张因子（EDRF）合成前体—左旋精氨酸（LArg）对急性心肌梗死（AMI）患者心功能和心律失常的影响。方法 AMI患者32例，在接受常规治疗的同时加用LArg一疗程（7~ 10 d），对照组33例在常规治疗的同时加用极化液一疗程，每日作心电监测并记录心律失常，超声测定心功能参数。结果 LArg治疗组左室收缩和舒张功能参数显著改善（P<0.05和P<0.01），心律失常发生率显著减少（P<0.05）。结论 LArg能改善AMI患者的心功能，降低室性心律失常的发生率。
Abstract:
AIM To demonstrate the effect of Larginine(LArg),precurson of endothelium-derived relaxing factor on cardiac function and the incidence of ventricular arrhythmia of patients with acute myocardiac infarction(AMI). METHODS Sixty five patients with AMI were divided into two groups randomly, 32 patients were treated with both routine medication and short term administration of LArg for 7 to 10 days,The cardiac function parameters were measured by echocardiography and various kinds of arrhythmia were monitored and counted every day, While in control group, 33 patients were administrated with routine medication and short term GIK instead of LArg, Cardiac function parameters and the incidence of arrhythmia were treated with the same method as above.RESULTS parameters reflecting ventricular systolic and diastolic function were improved better in LArg treated group than those in control group (P<0.05 and P<0.01), The incidence of ventricular arrhythmia in LArg group was lower than that in control group(P<0.05). CONCLUSION The results suggest that LArg yield some beneficial effects on improving cardiac function and lowering the incidence of ventricular arrhythmia in patients with AMI.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-03-26.
更新日期/Last Update: 2010-01-05