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急性冠脉综合征患者血清IL-18水平的检测及其意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第2期
页码:
142-144
栏目:
临床研究
出版日期:
2005-03-05

文章信息/Info

Title:
Detection and significance of serum IL18 in patients with acute coronary syndromes
作者:
刘安恒; 李兰荪; 张荣庆; 王星; 郭亮; 栾荣华
第四军医大学西京医院心血管内科，陕西 西安 710032
Author(s):
LIU Anheng; LI Lansun ; ZHANG Rongqing;  WANG Xing; GUO Liang; LUAN Ronghua
Department of Cardiovasology，Xijing Hospital，Fourth Military Medical University，Xi’an,Shaanxi 710032，China
关键词:
冠状动脉疾病; 白细胞介素18; 高敏C反应蛋白; 心肌肌钙蛋白
Keywords:
coronary disease; interleukin18; high sensitive Creactive protein; troponin
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 检测急性冠脉综合征（ACS）患者血清白细胞介素18（IL18）的水平，并探讨其与血清高敏C反应蛋白（hsCRP）及血清肌钙蛋白I（cTnI）的关系。 方法 用ELISA法检测ACS患者74例,稳定型心绞痛 (SAP) 患者31例，及冠状动脉造影正常者22例（对照组l）血清IL18，同时免疫比浊法检测各组患者hsCRP，微粒子捕捉法检测cTnI。结果 ①ACS患者血清IL18、hsCRP与SAP组及对照组比较，均存在显著差异(P<0.01)。②急性心肌梗死(AMI)患者血清hsCRP较UAP患者显著升高(P<0.01)，而IL18在两组比较无显著差异（P>0.05）。③ACS患者hsCRP与IL18显著正相关。④AMI患者cTnI与IL18无显著相关。结论 IL18与急性冠脉综合征的发病密切相关，可作为急性冠脉综合征的一个新的重要的血清标志物。血清IL18及hsCRP正相关，提示多种炎症因子共同参与或相互作用参与了动脉粥样硬化的形成及急性冠脉综合征的发病过程。
Abstract:
AIM To measure the serum concentration of interleukin18（IL18）in patients with acute coronary syndromes and investigate its relation with high sensitive Creactive protein（hsCRP）and cardiac troponin（cTnI）. METHODS The serum concentrations of IL18，hsCRP and cTnI were measured in 31 patients with stable angina pectoris(SAP)，74 patients with acute coronary syndromes (ACS) and 22 controls（control）undergoing coronary angiography (CAG) by enzymelinked immunosorbent assay（ELISA）or immunonephelometric assay or microparticle capture enzyme immunoassay. RESULTS ①The serum levels of IL18 and hsCRP were significantly increased in ACS in comparison with SAP and control (P<0.01)；②No difference in IL18 was found between patients with unstable angina pectoris(UAP) and those with acute myocardial infarction(AMI)(P>0.05),but the serum concentration of hsCRP was higher in patients with AMI than those with UAP (P< 0.05)； ③The serum concentration of IL18 was correlated with hsCRP in ACS； ④Not similar to hsCRP,the serum concentration of IL18 was not correlated with cTnI in patients with AMI. CONCLUSION Serum IL18 concentration was significantly increased in patients with ACS and it can be a new and important serum marker in ACS.

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备注/Memo

备注/Memo:
收稿日期：2004-09-16.
更新日期/Last Update: 2010-01-05