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|本期目录/Table of Contents|

扩张型心肌病血清Ⅰ型、Ⅲ型前胶原水平与左室结构及收缩功能的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第2期
页码:
149-151
栏目:
临床研究
出版日期:
2005-03-05

文章信息/Info

Title:
Relationship between levels of serum typeⅠ and Ⅲ procollagen and left ventricular structure, systolic function in patients with dilated cardiomyopathy
作者:
孙桂芳1; 刘凤岐1;  孙萍2;  孙波2
1.哈尔滨医科大学第一临床医学院心内科，黑龙江 哈尔滨 150001；2. 黑龙江省第五医院彩超室
Author(s):
SUN Guifang1;  LIU Fengqi1;  SUN Ping2;  SUN Bo2
1. Department of Cardiology, First Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150001; 2. Department of Ultrasound, Fifth Hospital of Heilongjiang, Harbin, Heilongjiang 150018
关键词:
心肌病; 扩张型; 前胶原; 血清; 心功障碍; 左室
Keywords:
cardiomyopathy; dilated;  procollagen;  serum;  ventricular dysfunction; left
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 研究扩张型心肌病（IDCM）血清Ⅰ型、Ⅲ型前胶原（PCⅠ、PCⅢ）水平与左室结构及收缩功能的关系。方法 IDCM患者53例，健康人32例为对照组，应用放射免疫法测定血清PCⅠ、PCⅢ，应用超声心动仪测量左室结构指标及左室射血分数(LVEF)。分析IDCM血清PCⅠ、PCⅢ与左室结构指标、LVEF关系。结果 IDCM组血清PCⅠ、PCⅢ高于对照组（P<0.01）。简单线性相关分析揭示IDCM血清PCⅠ、PCⅢ分别与舒张末期左室内径、左室质量指数（LVMI）正相关（P<0.05），与LVEF负相关（P<0.01）。多元逐步回归分析显示血清PCⅠ、PCⅢ分别与LVEF负相关，与左室结构指标无相关性(P>0.05)。结论 IDCM血清PCⅠ、PCⅢ升高；反映左室收缩功能降低。
Abstract:
AIM To study the relationship between levels of serum typeⅠ and Ⅲ procollagen (PCⅠ, PCⅢ) ，and left ventricular structure and systolic function in patients with dilated cardiomyopathy (IDCM). METHODS Serum PCⅠ and PCⅢ were measured by radioimmunoassay in 53 IDCM patients and 32 healthy people. Left ventricular structure indexes and ejection fraction (LVEF) were obtained by echocardiography. Relationship between serum PCⅠ and PCⅢ， and left ventricular structure indexes, LVEF was assessed. RUSULTS Serum PCⅠand PCⅢ were higher in the IDCM patients than in the healthy people (P<0.01). Simple linear correlation analysis showed serum PCⅠand PCⅢ were respectively positively related to enddiastolic left ventricular diameter and left ventricular mass index (LVMI) (P<0.05), negatively related to LVEF (P<0.01); while by multivariate stepwise regression analysis, serum PCⅠand PCⅢ were negatively related to LVEF (P<0.01),but was not correlated with left ventricular structure indexes (P>0.05). CONCLUSION Serum PCⅠand PCⅢ were higher in the IDCM patients. The worse left ventricular contractive function appeared.

参考文献/References

［1］ 任崇雷, 刘维永, 张近宝, 等. 血清细胞外基质用于评价风湿性心脏病心肌纤维化［J］. 中华胸心血管外科杂志, 2001, 17(5): 291-293.

［2］ Schapter JA, Speiser B. The extracellular matrix in the failing human heart［J］. Basic Res Cardiol, 1992, 87(SupplⅠ): 303-309.

［3］ Klappacher G, Franzen P, Haab D, et al. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dialted cardiomyopathy and impact on diagnosis and prognosis［J］. Am J Cardiol, 1995, 75 (14): 913-918.

［4］ 申源生, 侯文振, 马伟东, 等. 抗纤维化治疗对慢性心力衰竭患者血清纤维化指标的影响［J］. 心脏杂志, 2002, 14(4): 316-317.

［5］ Beltrami CA, Finato N, Rocco M, et al. The cellular basis of dilated cardiomyopathy in humans［J］. J Mol Cell Cardiol, 1995, 27(1): 291-305.

备注/Memo

备注/Memo:
收稿日期：2004-06-28.资金项目：黑龙江省“十五”科技攻关项目(编号：GB01C12603)
更新日期/Last Update: 2010-01-05