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|本期目录/Table of Contents|

国产镍钛记忆合金房间隔封堵器的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第3期
页码:
240-243
栏目:
介入治疗
出版日期:
2005-05-05

文章信息/Info

Title:
The experimental study of atrial septal defect with the domestic TiNi memory alloy closure device
作者:
盛晓棠;  朱鲜阳
沈阳军区总医院先心病内科，辽宁 沈阳 110016
Author(s):
Sheng Xiaotang; Zhu Xianyang
Department of Congenital Heart Disease Medicine, General Hospital of Shenyang Army, Shenyang,Liaoning 110016, China
关键词:
封堵器; 房间隔缺损; 疾病模型; 动物; 狗
Keywords:
closure device;  atrial septal defect;  disease models;  animal; dogs
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的 通过外科创建的房间隔缺损动物模型评价国产镍钛记忆合金封堵器的封堵效果和组织学反应。 方法 将犬房间隔造口建立房间隔缺损动物模型后，利用国产镍钛记忆合金房间隔封堵器进行封堵，术后4 h、15 h、1、2、3个月分别进行大体解剖和光镜、电镜检查。 结果 5只犬成功建立了动物模型并1次封堵成功，完成4 h～3个月随访。动物生长发育正常，无严重并发症出现。15 d～3个月大体解剖可见封堵器与房间隔组织紧密嵌合，表面完全被一层半透明、光滑的新生组织所覆盖，光镜及透射电镜检查证实为内皮样细胞。 结论 国产镍钛记忆合金封堵器封堵外科创建的房间隔缺损动物模型是可行的。
Abstract:
AIM To evaluate the embolized effect and the reaction of histology of a new domestic TiNi memory alloy closure device in a canine model. METHODS The atrial septal defect (ASD) models were established by ASD stoma and closed by a new domestic TiNi memory alloy closure device. Followup the heart autopsy, light microscope, transmission electron microscope (TEM) examination were performed at four hours, fifteen days, one month, two months and three months after device implantation to observe resident shunts. RESULTS The ASD models were successfully established in five dogs. The procedures were technically successful in five dogs. The device were covered by a smooth and glistening organization which was conformed to be fibrous neoendothelium by light microscope and TEM. CONCLUSION The new domestic TiNi memory alloy closure device was feasible to be used to close the ASD in animal model.

参考文献/References

［1］Thanopoulos BD, Laskari CV, Tsaousis GS, et al. Closure of atrial septal defects with the amplatzer occulusion device: preliminary results［J］. J Am Coll Cardol, 1998, 31: 1110-1116.

［2］薛淼. 镍钛记忆合金的医学基础研究［J］. 中国生物医学工程学报，1983，2: 28.

［3］王小祥，毛志远，曹征旺,等. TiNi形状记忆合金腐蚀及细胞毒性的研究［J］. 中国生物医学工程学报，1996，15: 374-377.

［4］马根山. 镍钛形状记忆合金血管内支架组织相容性实验研究［J］. 中国生物医学工程学报，1995，14: 198-200.

备注/Memo

备注/Memo:
收稿日期：2004-12-30.
更新日期/Last Update: 2010-01-05