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|本期目录/Table of Contents|

雷帕霉素洗脱支架在急性心肌梗死紧急介入治疗中的应用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第3期
页码:
244-245，248
栏目:
介入治疗
出版日期:
2005-05-05

文章信息/Info

Title:
Rapamycineluting stents for the treatment of acute myocardial infarction
作者:
赵慧强; 贾国良; 郭文怡; 王海昌; 秦涛; 李成祥; 李伟杰; 吕安林; 李虎; 王晓燕
第四军医大学西京医院心内科，陕西 西安 710032
Author(s):
ZHAO Huiqiang; JIA Guoliang; GUO Wenyi; WANG Haichang; QIN Tao; LI Chengxiang; LI Weijie; L Anlin; LI Hu; WANG Xiaoyan
Department of Cardiology，Xijing Hospital，Fourth Military Medical University, Xi’an，Shaanxi 710032，China
关键词:
心肌梗塞; 急性; 雷帕霉素; 支架
Keywords:
myocardial infarction; acute; rapamycin; stent
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 探讨雷帕霉素洗脱支架（cypherTM）在急性心肌梗死（AMI）紧急介入治疗中应用的安全性及有效性。方法 回顾分析我科行紧急介入治疗并置入cypherTM支架的58例AMI患者（其中ST段抬高性AMI 41例，非ST段抬高性AMI 17例）的即刻疗效和随访结果。结果 58例患者紧急介入治疗均获得成功，58支梗死相关血管的罪犯病变共置入65枚cypherTM支架。住院期间未发生有关的严重并发症。3~12（7±4）月随访期内，2例患者因再次胸痛入院，其中1例经造影证实为其他冠脉分支新病变，1例为普通支架内再狭窄，行再次介入治疗。其余患者随访期内未出现心脏事件。58例患者共有11例复查了冠脉造影，CypherTM支架内均无再狭窄。结论 cypherTM支架在AMI的紧急介入治疗中安全有效。
Abstract:
AIM To investigate safety and efficacy of rapamycin eluting stent(cypherTM) implanting in patients with acute myocardial infarction(AMI) receiving emergency percutaneous coronary intervention. METHODS To retrospectively anglyze the immediate angiographic and clinic followup outcomes of 58 patients receiving CypherTM. RESULTS 58 lesions of 58 patients were treated and 65 CypherTM stents were successfully implanted.No serious complications were found in the term of operation and in hospital. Clinical followup of 58 patients were conducted for 7.4±4.0 months, there were no cardiac events except for 2 patients occurring angina pectoris.Repeat angiography was done in 2 patients,one occured restenosis in bare stents,and the other developed new lesion in other coronary artery.Repeat angiography was performed at 11 of 58 patients,no restenosis occurred in all CypherTM stents. CONCLUSION CypherTM stent is safe and effective in the treatment of AMI.

参考文献/References

［1］Suzuki K, Kopia G, Bailey L,et al.Stentbased delivery of sirolimus reduces neointimal formation and instent restenosis in a porcine coronary model［J］. Circulation, 2001,104:1188-1193.

［2］Sousa JE, Costa MA, Sousa AG,et al. Twoyear angiographic and intravascular ultrasound followup after implantation of sirolimuseluting stents in human coronary arteries［J］. Circulation, 2003,107(3):381-383.

［3］ Morice MC,Serruys PW,Sousa JE,et al.A randomized comparison of a sirolimuseluting stent with a standard stent for coronary revascularization［J］. N Engl J Med,2002,346:1773-1780.

［4］ Moses JW, Leon MB, Popma JJ,et al. Sirolimuseluting stents versus standard stents in patients with stenosis in a native coronary artery［J］. N Engl J Med, 2003,349(14):1315-1323.

［5］ Lemos PA, Saia F, Hofma SH,et al. Short and longterm clinical benefit of sirolimuseluting stents compared to conventional bare stents for patients with acute myocardial infarction［J］. J Am Coll Cardiol, 2004,43(4):704-708.

备注/Memo

备注/Memo:
收稿日期：2004-07-15.
更新日期/Last Update: 2010-01-05