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Title:: Serum aldosteron changes in chronic heart failure

作者:: 陈东海; 季乃军; 童丽军; 樊必夫; 王成尧; 梅益斌; 李付远; 考验; 浙江省丽水市人民医院,温州医学院附属第六医院，浙江丽水 323000

Author(s):: CHEN Donghai; JI Naijun; TONG Lijun; FAN Bifu; WANG Chengyao; MEI Yi bin; LI Fuyuan; KAO Yan; Department of Cardiology,Lishui Municipal Hospital，Lishui, Zhejiang 323000,China

关键词:: 心力衰竭; 慢性; 醛固酮; 放射免疫法

Keywords:: chronic heart failure; aldosterone; radioimmunoassay

分类号:: R541.6

DOI:: -

文献标识码:: A

摘要:: 目的探讨慢性心力衰竭(CHF)患者血浆醛固酮(ALD)水平的变化及其临床意义。方法采用放射免疫法测定CHF患者280例和无心力衰竭患者80例的血浆ALD水平，进行对比统计分析。结果 CHF组血清ALD水平(167±32 ng/L)显著高于对照组(79±28 ng/L)(P<0.01)，而且在Ⅱ、Ⅲ、Ⅵ级心力衰竭组间依次显著递增(F=71.03，P<0.01)，住院期间死亡组血清ALD水平显著高于好转出院组(P<0.05)。结论 CHF患者血浆ALD水平显著升高，且与心力衰竭严重程度和病情预后相关。

Abstract:: AIM To investigate the changes of Aldosterone(ALD) in patients with chronic heart failure(CHF). METHODS Serum ALD was studied in 280 CHF by radioimmunoassay,80 noCHF patients were served as control. RESULTS Serum ALD was increased significantly in CHF compared with that in the control group( t=22.09,P<0.01 ). and the mean serum ALD levels increase by degrees in different step patients (NYHA, Ⅱ,Ⅲ,Ⅳ) ( F=71.03，P<0.01).In died CHF patients， Serum ALD was significantly highter than in nodied patients(t=2.523,P<0.05). CONCLUSION ALD were increased in CHF patients, and more in died patients.

参考文献/References

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［4］郭志琴，刘坤申，彭应心，等. 螺内酯对慢性心力衰竭患者醛固酮水平及心功能的影响［J］. 中国循环杂志, 2002,17(2):269-271.

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慢性心力衰竭患者血清醛固酮水平的变化及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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