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外周血CD34+细胞数在有危险因素的急性心肌梗死患者中的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第4期
页码:
367-370
栏目:
临床研究
出版日期:
2005-09-05

文章信息/Info

Title:
Change of CD34+ progenitor cells number in peripheral blood of acute myocardial infarction patients with cardiovascular risk factors
作者:
阎爱国; 荣芳; 李丽
西安交通大学第二医院 ，陕西 西安 710006
Author(s):
XUE Jiahong;  LI Lijun; LUO Liang
Department of Emergency, Second Hospital, Xi’an Jiaotong University, Xi’an,Shaanxi 710006, China
关键词:
心血管危险因素; 心肌梗塞; 急性; CD34+前体细胞
Keywords:
cardiovascular risk factors;  myocardial infarction; acute ; CD34+ progenitor cells
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 健康人外周血中前体CD34+细胞数目很少,但在急性缺血时，这些细胞可以从骨髓动员到外周血。研究发现，有心血管危险因素的患者,外周血CD34+细胞数目是减少的。然而，有心血管事件危险因素的患者，急性心肌梗死是否能促进CD34+细胞的动员，目前尚不完全清楚。方法 42例心血管事件危险因素患者被分成两组：急性心肌梗死组20例, 无冠状动脉粥样硬化性心脏病组22例。 同时,没有冠心病及任何心血管病危险因素的16例自愿者入选为健康对照组。流式细胞仪分析外周血CD34+细胞数目。结果 急性心肌梗死组, 外周血CD34+细胞的数目为 (1.915±0.667)/μl，与健康对照组(1.925±0.629)/μl值比较， P=0.963。无冠状动脉粥样硬化性心脏病组, 外周血CD34+细胞的数目为(1.804±0.605)/ μl。在心肌梗死组与无冠心病组间比较，外周血CD34+细胞的数目无明显不同（P=0.575）。而且，患者并存心血管危险因素的多少与外周血中CD34+细胞水平似乎成反向相关。结论 有心血管事件危险因素患者，发生急性心肌梗死后外周血前体CD34+细胞未发现增加。由此提示心血管病危险因素可能抑制急性缺血诱导的前体CD34+ 细胞的动员，且与危险因素多少相关。
Abstract:
AIM Evidence demonstrates that the circulating CD34+ progenitor cells in healthy people are very few;however, they can be mobilized into peripheral blood from bone marrow (BM) in response to acute myocardial ischemic events and contribute to regeneration of myocardial tissues. Studies have shown that various cardiovascular risk factors can influence mobilization of CD34+ cells. This study was conducted to investigate the change in circulating CD34+ cells of patients with cardiovascular risk factors during acute myocardial infarction (AMI). METHODS 42 patients with cardiovascular risk factors were classified into 2 groups: patients with acute myocardial infarction (n=20) and patients without coronary artery disease (n=22). 16 volunteers without any evidence of cardiovascular risk factors and coronary artery diseases were chosen as healthy controls. The number of CD34+ cells in peripheral blood (PB) was analyzed by flow cytometer. RESULTS The number of circulating CD34+ cells was (1.915±0.667)/μl in AMI patients as against (1.925±0.629)/μl in healthy controls（P=0.963） and (1.804±0.605)/μl in patients without CAD. There was no significant difference between patients with AMI and patients without CAD (P=0.575). Moreover, an inverse correlation between circulating CD34+ progenitor cells and the number of risk factors was detected. CONCLUSION Circulating CD34+ progenitor cells do not increase in AMI patients with cardiovascular risk factors. It is suggested that acuteischemiainduced mobilization of CD34+ precursor cells may be inhibited by cardiovascular risk factors, which is correlated with the number of risk factors.

参考文献/References

［1］ Tiwari A, Hmilton G, Seifalian AM, et al. Regarding “isolation of endothelial cells and their progenitor cells from human peripheral blood”［J］. J Vasc Surg, 2002, 35:827.

［2］ Hristov M, Erl W, Weber PC. Endothelial progenitor cells mobilization, differention ,and homing［J］. Arterioscler Thromb Vasc Biol, 2003, 23: 1185-1189.

［3］ Orilic D. Adult bone marrow stem cells regenerate myocardium in ischemic heart disease［J］. Ann N Y Acad Sci, 2003, 996:152-157.

［4］ Asahara T, Kalka C, Masuda H, et al. Ischemia and cytokineinduced mobilization of bonemarrowderived endothelial progenitor cells for neovascularizarion［J］. Nat Med, 1999, 5:434-438.

［5］ Mutin M, Canavy I, Blann CA, et al. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells［J］. Blood, 1999, 93(9): 2951-2958.

［6］ Shintani S, Murohara T, Ikeda H, et al. Mobilization of endothelial progenitor cells in patients with myocardial infarction［J］. Circulation, 2001, 103: 2776-2779.

［7］ Rafii SH, Meeus S, Dias S, et al. Contribution of marrowderived progenitors to vascular and cardiac regeneration［J］. Dev Biol, 2002, 13:61-67.

［8］ Masuda H, Kalka C , Takahashi T, et al. The effect of progesterone on endothelial progenitor cell kinetics for physiological neovascularization of uterus［J］. Circulation, 1999,100（suppl I）: I691-I692.（Abstract）

［9］ Masuda H, Kalka C, Takahashi T,et al. Regulatory role of estrogen on endothelial progenitor cell kinetics for cyclic endothmetrial neovascularization［J］. Circulation，1999, 100（suppl I）: I475.（Abstract）

［10］ 北京市临床流式细胞分析协作组. 流式细胞术三色分析调查成年人外周血CD34+造血干细胞绝对计数参考范围［J］. 中华检验医学杂志, 2002，25(1): 58-60.

［11］ Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease［J］. Circ Res，2001，89:e1.

［12］ Hill JM, Zalos G, Halcox JP. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk［J］. N Engl J Med, 2003，348:593-600.

［13］ Losordo DW，Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease［J］. Circulation, 2004，109:2692-2697.

备注/Memo

备注/Memo:
收稿日期：2004-09-15.基金项目：国家自然科学基金资助项目，批准号：3037059
更新日期/Last Update: 2010-01-05