洛汀新对原发性高血压患者NOS活性及NO的影响(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2005年第4期
- 页码:
- 371-372,375
- 栏目:
- 临床研究
- 出版日期:
- 2005-09-05
文章信息/Info
- Title:
- Effect of Lotensin on NOS activity and NO level in patients with essential hypertension
- Author(s):
- XU Hongtao1; GAO Lianru1; ZANG Yimin2; WANG Jun2
- 1．Department of Cardiology, General Navy Hospital， Beijing 100036； China; 2.Department of Physiology, Fourth Military Medical University, Xi′an， Shaanxi 710032，China
- 关键词:
- 高血压; 原发性; 血管紧张素转换酶抑制剂; 一氧化氮合成酶; 一氧化氮
- Keywords:
- hypertension; angiotensionconverting enzyme inhibitors; nitric oxide synthase; nitric oxide
- 分类号:
- R544.1
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 探讨血管紧张素转换酶抑制剂洛汀新对原发性高血压（EH）患者的降压作用及其对NO和NOS水平的影响。方法 采用每日1次洛汀新10 mg治疗EH患者(21例)8周,观察治疗前、后血压和血小板（Pt）NO水平及NOS活性的变化。结果 EH患者Pt的NOS活性和NO水平显著低于正常对照组（14例）（P<0.01）。经洛汀新治疗后EH患者的血压显著降低（P<0.01），Pt的NO产生量及NOS活性显著升高（P<0.01）。结论 洛汀新可降低血压、调节血小板NOS的活性和NO分泌量。
- Abstract:
- AIM To investigate the effect of ACEI (Lotensin) on blood pressure (BP),NO production and NOS activity in patients with essential hypertension(EH).METHODS 21 EH patients were treated with Lotensin everyday for 8 weeks. Before and after the treatment, the BP level, the NO production and NOS activity were measured. RESULTS In EH patients, the production of NO and the activity of NOS were significantly lower than those in normal (P<0.01). After the treatment of ACEI, blood pressure decreased significantly, the NO production and NOS activity increased significantly (P<0.01). CONCLUSION ACEI(Lotension) has antihypertensive effect, simultaneously, it increases NOS activity and NO production of platelet in EH patients.
参考文献/References
［1］ Dananberg J,Bider RS,Grekin RJ. Sustained hypertension induced by oral administer NitroLArg ［J］. Hypertens，1993，21:356-359.
［2］ 杨春娥，张三奇，石玉，等. 近年来高血压病药物及其综合治疗的概述［J］ . 心脏杂志，2002，14（6）：550-551.
［3］ 从洪良，黄体钢，杨万松，等. 依那普利对肾性高血压大鼠RAS系统及NO影响的实验研究［J］. 2000,8(2):169-171.
［4］ 董尔丹，石山. 阿司匹林与维拉米并用对血小板聚集与血栓形成的影响［J］.中国药理学报，1990，6（6）：375-378.
［5］ Tony M,Cadwgan D,Nigel B.Evidence for altered platelet nitric oxide synthesis in essential hypertenstion［J］. J Hypertens, 1993,114:417-419.
［6］ 高连如，赵云涛，石湘云，等. 右旋硝基精氨酸诱导大鼠持续性高血压［J］. 基础医学与临床试验, 1995,15：49-52.
［7］ 王军，徐洪涛，姚星海，等. 高血压患者血小板L精氨酸/一氧化氮系统的改变［J］. 高血压杂志,1998,6(1):22-24.
备注/Memo
- 备注/Memo:
- 收稿日期：2004-11-20.
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更新日期/Last Update: 2010-01-05