高血压病患者动脉血管组织中PPARγ的表达(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2005年第5期
- 页码:
- 416-418
- 栏目:
- 基础研究
- 出版日期:
- 2005-10-05
文章信息/Info
- Title:
- The expression of peroxisome proliferatoractivated receptor γ in the artery tissues of essential hypertensive patients
- 作者:
- 李永勤1; 牛小麟1; 4; 李少民2; 马建仓3
- 西安交通大学:1.第二医院心内科，2.第二医院普外科，3.第二医院心外科，陕西 西安 710004;4. 环境与疾病相关基因教育部重点实验室，陕西 西安 710061
- Author(s):
- LI Yongqin; NIU Xiaolin; LI Shaomin; MA Jiancang
- Department of Cardiology,Second Hospital of Xi′an Jiaotong University, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Shaanxi, Xi′an 710004,China
- 关键词:
- 高血压; 过氧化物酶体激活物增殖受体γ; 免疫组织化学
- Keywords:
- essential hypertension; PPARγ; immunohistochemistry
- 分类号:
- R541.3
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 了解过氧化物酶体激活物增殖受体γ（peroxisome proliferator-activated receptor γ，PPARγ）在高血压病患者血管组织中的表达，以及不同年龄患者间表达的差异。方法 收集高血压病患者及正常血压者手术废弃组织中的动脉血管，采用免疫组化法结合图像信号分析技术，检测动脉血管组织内膜及中膜中PPARγ的表达。 结果 高血压病组动脉血管组织中PPARγ的表达显著高于血压正常组（P<0.05）；而>65岁高血压病组动脉血管组织中PPARγ的表达高于<65岁高血压病组（P<0.05）。结论 高血压病患者血管组织中PPARγ的表达升高，且随着年龄的增长，PPARγ的表达增高更加明显。提示PPARγ与高血压病的发生及发展相关。
- Abstract:
- AIM To study the expression of PPARγ in arterial tissues of patients with essential hypertension and its change during aging. METHODS Samples of arteries of both hypertensive subjects and normotensive controls after surgeries were collected for immunohistochemical analysis of PPARγ expression. RESULTS The expression of PPARγ was significantly higher in arterial vasculature in hypertensive patients than that in normotensive controls (P<0.05 ), and that in the patients over 65 years was the highest. CONCLUSION An increased level of vascular PPARγ expression in hypertensive patients and its positive correlation with ages suggest that PPARγ may be related to the development of hypertension.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2005-03-01.基金项目：陕西省科技攻关项目资助（No.2004K14G1）
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