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急性心肌梗死患者血脑钠尿肽前体N末端的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第5期
页码:
468-470
栏目:
临床研究
出版日期:
2005-10-05

文章信息/Info

Title:
Changes of blood natriuretic peptide levels in patients with acute myocardial infarction
作者:
黄高忠1; 顾军2; 汤晔华1; 顾鹏飞21;  吴宗贵1; 吴歆华1; 殷仁富1
第二军医大学长征医院:1.心内科,2.检验科, 上海 200003
Author(s):
HUANG Gaozhong; GU Jun; TANG Yehua;  GU Pengfei; WU Zonggui; WU Xinhua; YIN Renfu
Department of Cardiology,Changzheng Hospital, Second Military Medial University, Shanghai 200003,China
关键词:
心肌梗塞; 急性; 钠尿肽;  脑钠尿肽前体N末端; 心功能
Keywords:
myocardial infarction; acute; natriuretic peptide; NTproBNP; cardiac function
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 观察B型脑钠尿肽前体N末端（NTproBNP）在急性心肌梗死（AMI）患者的变化。方法 应用电化学发光－夹心免疫分析法检测26例首次发生的ST段抬高型透壁性心肌梗死患者的血NTproBNP,分析其与肌酸激酶MB同工酶、梗死部位和心功能的关系。对照组采用经临床和超声心动图检查无心脏结构和功能异常或其它伴随疾病的轻度高血压或稳定劳力性心绞痛患者22例。结果 AMI患者血NTproBNP显著高于正常心功能对照组(2097±2008 ng/L vs 70±51 ng/L，P<0.01）。心功能≥Ⅱ级组血NTproBNP显著高于心功能Ⅰ级组,分别为3172.6±2448.9 ng/L 和1175±710.0 ng/L（P<0.01）。NTproBNP与Killip分级呈正相关。结论 AMI后心脏钠尿肽系统激活，其改变与心功能分级有关，但无心室功能障碍和心房压升高者亦显著升高。
Abstract:
AIM To observe changes of blood Nterminal fragment of brain natriuretic peptide prohormone(NTproBNP ) levels in patients with acute myocardial infarction(AMI). METHODS NTproBNP levels were measured with electrochemiluminescence immunoassay and its relationship with creatine kinaseMB， infarct location and left ventricular function was analysed. Twentytwo patients with uncomplicated mild hypertension or stable exertive angina who had normal heart function were selected as the control subjects. RESULTS Levels of serum NTproBNP increased significantly in patients with AMI compared with those in the control (2097±2008 ng/L vs 70±51 ng/L,P<0.01) . Among AMI patients,those with left ventricular disfunction（KillipⅡ-Ⅳ） had higher blood NTpro BNP levels than those with normal heart function(Killip Ⅰ)(3173±2449 ng/L vs 1175±710 ng/L,P<0.01). CONCLUSION Serum NTproBNP levels increase during AMI(with or without heart failure) and has a positive corelation with Killip classification.

参考文献/References

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［2］Morita E,Yasue H,Yoshimura M,et al. Increased plasma level of BNP in patients with AMI［J］. J Am Coll Cardiol，1993，88:82-91.

［3］Talwar S，Squire IB， Downie PF，et al. Profile of plasma Nterminal proBNP following acute myocardial infarction; correlation with left ventricular systolic dysfunction［J］. Eur Heart J，2000，21(18): 1514-1521.

［4］Richards AM,Nicholls MG,Yandle TG,et al. Plasma NTproBNP and adrenomedulin.New neurohormonal predictors of left ventricular dysfunction and prognosis after myocardial infarction［J］. Circulation，1998,97:1921-1929.

［5］Sabatine MS. Multimarker approach to risk stratification in nonST elevation acute coronary syndromes: simultaneous assessment of troponin I, Creactive protein, and Btype natriuretic peptide［J］. Circulation，2002，105(15): 1760-1763.

［6］Omland T, Persson A, Ng L, et al. Nterminal proBtype natriuretic peptide and longterm mortality in acute coronary syndromes［J］. Circulation，2002，106: 2913-2918.

备注/Memo

备注/Memo:
收稿日期：2004-09-16.
更新日期/Last Update: 2010-01-05