我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血脂指标对冠心病危险性预测的性别差异(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第6期
页码:
573-575
栏目:
临床研究
出版日期:
2005-12-05

文章信息/Info

Title:
Sex differences in predictive value of serum lipids as risk factors for coronary disease
作者:
徐凯1;  韩雅玲2;  佟铭2;  杨桂棠2;  董伟2;  王凡非2
1．第四军医大学西京医院心内科，陕西 西安 710032；2．沈阳军区总医院心内科，辽宁 沈阳 110016
Author(s):
XU Kai1; HAN Yaling2; TONG Ming2; YANG Guitang2; DONG Wei2; WANG Fanfei2
1.Department of Cardiology, Xijing Hospital,Fourth Military Medical University，Xi′an,Shaanxi 710032,China; 2.Department of Cardiology, General Hospital of Shenyang Military Command,Shenyang,Liaoning 110016,China
关键词:
冠状动脉疾病; 血脂; 冠状动脉造影; 性别
Keywords:
coronary disease; serum lipid; coronary angiograhy; sex
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 通过对血脂指标与冠心病发病之间关系的探讨，阐明各种血脂指标对冠心病危险性的预测价值是否存在性别差异。方法 对1997年9月~2004年6月在我科行选择性冠状动脉造影术（SCA）的患者资料进行回顾性分析。根据造影结果各分为两组：冠心病（CAD+）组和对照（CAD-）组。造影前1 d空腹抽取静脉血，测定血脂水平。结果 共分析6806例患者，其中男性4881例，女性1925例。根据造影结果分组，女性CAD-组有811例，CAD+组有1114例。男性CAD-组有1255例，CAD+组有3626例。女性两组间的总胆固醇（TC)、甘油三酯（TG)、载脂蛋白B（apoB)、高密度脂蛋白胆固醇（HDLC)、低密度脂蛋白胆固醇（LDLC)及非高密度脂蛋白胆固醇（nonHDLC) 相差非常显著（均P<0.01），而载脂蛋白A（apoA）及TC/HDLC无显著差异(均P>0.05)；男性两组间的TC (P<0.01)、HDLC (P<0.01)、LDLC (P=0.05)及nonHDLC (P<0.01) 相差显著，而TG、apoA、apoB及TC/HDLC无显著差异(均P>0.05)。应用Logistic回归模型对年龄及各项血脂指标进行多因素分析。女性患者只有apoB进入方程，男性患者中只有TC进入方程。结论 预示冠心病发病的最有价值的血脂指标在男性及女性分别是血清TC和apoB。
Abstract:
AIM To elucidate whether there are differences between men and women in predictive power of serum lipids as risk factors for coronary artery disease(CAD) . METHODS The total of 6806 patients undergoing coronary angiography were studied from September 1997 to June 2004 in our department. Patients were divided into two groups:Group 1 (CAD+) consisted of patients at least one main coronary artery with ≥50% stenosis and group 2 (CAD-) patients with none of the coronary arteries significantly obstructed (<50%). Before coronary angiography, blood samples after overnight fasting were collected for the determination of serum lipids including cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDLC), high density lipoprotein (HDL), apolipoprotein A(apoA) and apolipoprotein A(apoB). RESULTS CAD+ women (n=1114) had higher plasma levels of apoB (P<0.01), TC (P<0.01), TG(P<0.01),LDLC (P=0.003),nonHDLC (P<0.01) and lower HDLC (P<0.01) than CAD- women (n=811).CAD+ men (n=3626) had higher plasma concentrations of TC(P<0.01), LDLC (P=0.05), nonHDLC (P<0.01) and lower levels of HDLC (P<0.01) than CAD-men (n=1255). Only apoB and TC were found to be independent risk factors for CAD in women and men respectively among lipid components by Logistic regression analysis. CONCLSION ApoB (for women ) and TC (for men) are more valuable than other lipid parameters in predicting coronary disease.

参考文献/References

［1］ Fukushima H, Sugiyama S, Honda O, et al. Prognostic value of remnantlike lipoprotein particle levels in patients with coronary artery disease and type II diabetes mellitus［J］. J Am Coll Cardiol，2004，43(12):2219-2224.

［2］ von Muhlen D, Langer RD, BarrettConnor E. Sex and time differences in the associations of non-highdensity lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study)［J］. Am J Cardiol， 2003，91(11):1311-1315.

［3］ Castanho VS, Oliveira LS, Pinheiro HP, et al. Sex differences in risk factors for coronary heart disease: a study in a Brazilian population［J］. BMC Public Health， 2001，1(1):3.

［4］ Ford ES, Mokdad AH, Giles WH, et al. Serum total cholesterol concentrations and awareness, treatment, and control of hypercholesterolemia among US adults: findings from the National Health and Nutrition Examination Survey, 1999 to 2000［J］. Circulation， 2003，107(17):2185-2189.

［5］Nielsen NE, Olsson AG, Swahn E. Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics［J］. J Intern Med， 2000，247(1):43-52.

［6］Ballantyne CM, Andrews TC, Hsia JA, et al. Correlation of nonhighdensity lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on nonhighdensity lipoprotein cholesterol levels［J］. Am J Cardiol， 2001，88(3):265-269.

备注/Memo

备注/Memo:
收稿日期：2004-09-06.作者简介：徐凯，主治医师，博士生Tel：（024）23051599 Email：xukui2001@sina.com
更新日期/Last Update: 2010-01-06