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钙调素依赖蛋白激酶Ⅱ在心肌肥厚中转导核钙信号的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第6期
页码:
607-609
栏目:
综述
出版日期:
2005-12-05

文章信息/Info

Title:
-
作者:
周骐; 刘 健 综述; 肖颖彬 审校
第三军医大学新桥医院心血管外科，重庆 400037
Author(s):
-
关键词:
钙调素依赖蛋白激酶Ⅱ; 心肌肥厚; 基因
Keywords:
-
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
钙调素依赖蛋白激酶Ⅱ（CaMKⅡ）是一种多功能的蛋白激酶，作为Ca2+信号转导的关键因子，能够调节细胞多种功能。CaMKⅡ的δ亚基是心脏中的主要成分，其中δB位于细胞核，能够调节肥厚相关基因表达，也能转导凋亡信号。本文主要对CaMKⅡ的δB亚基的结构、在心肌肥厚过程中发挥的作用以及如何转导核钙信号来调节基因转录和有关凋亡的内容作一简述。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-10-13.基金项目：国家自然科学基金项目资助（No.30200108）作者简介：周骐，主治医生，博士生Tel：(023)68774607 Email：Drzhouqi@tom.com
更新日期/Last Update: 2010-01-06