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Title:: Management of persistent atrial fibrillation with intravenous administration of metoprolol

作者:: 官功昌¹; 王东琦¹; 李宏波²; 陈新义¹; 寿锡凌¹; 刘新宏¹; 王亚丽²; 梁磊²; 1.西安交通大学第一医院心内科，陕西西安 710061； 2. 陕西省人民医院心内科，陕西西安 710068

Author(s):: GUAN Gong-chang¹; WANG Dong-qi¹; LI Hong-bo²; CHEN Xin-yi²; SHOU Xi-ling²; LIU Xin-hong²; WANG Ya-li²; LIANG Lei²; 1. Department of Cardiology， First Hospital of Xi'an Jiaotong University，Xi′an,Shaanxi 710061； 2. Department of Cardiology of Shaanxi Provincial Hospital, Xi'an, Shaanxi 710068, China

关键词:: 心房颤动; 美托洛尔; 去乙酰毛花苷; 心室率

Keywords:: atrial fibrillation; metoprolol; deslanoside; ventricular rate

分类号:: R541.75

DOI:: -

文献标识码:: A

摘要:: 目的观察美托洛尔静脉制剂用于控制持续性心房颤动时快速心室率的临床疗效和安全性。方法 58例持续性心房颤动患者分别接受了静脉美托洛尔（A组）和去乙酰毛花苷（B组）治疗。结果两组患者治疗后心室率明显降低， A组31例，心室率平均下降39±16次/min，最大效应时间30 min；B组27例，心室率平均下降30±9次/min，最大效应时间2 h；两组患者用药前后血压无明显变化，所有患者未因药物的副作用而终止治疗。结论美托洛尔静脉制剂能迅速有效、安全地控制持续性心房颤动时快速心室率反应。

Abstract:: AIM To evaluate the clinical efficacy and safety of intravenously administrated metoprolol in the management of ventricular tachyarrhythmia related to persistent atrial fibrillation. METHODS Of 58 patients with persistent atrial fibrillation, 31 were given metoprolol (group A) and 27 deslanoside (group B). RESULTS The ventricular rate of patients from both groups decreased obviously, with an average decrease by 39±16 /min and the maximum time of therapeutic effects of 30 minutes in group A, and 30±9 /min average decrease and 120minute maximum time of therapeutic effects in group B. The blood pressure did not change obviously in all the patients following the medication and none of them discontinued treatment earlier because of side effects. CONCLUSION The intravenous administration of metoprolol is an effective, expeditious and safe way to control the ventricular tachyarrhythmia related to persistent atrial fibrillation.

参考文献/References

［1］何勇, 郑强荪, 高敏娟, 等. 胺碘酮治疗心房颤动临床疗效的观察［J］. 心脏杂志, 2002, 14（5）: 393-395.

［2］蒋文平，朱俊，戚文航, 等. 如何对待心房颤动［J］. 中华心血管病杂志, 2003, 31(7) : 483-486.

［3］The Atrial Fibrillation Followup Investigation of Rhythm Management (AFFIRM) Invetigators. A comparison of rate control and rhythm control in patients with atrial fibrillation［J］. N Engl J Med, 2002, 347:1825-1833.

［4］中华医学会心血管病分会. 中国部分地区心房颤动住院病例回顾性调查［J］. 中华心血管病杂志, 2003, 31(12) : 913-916.

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静脉注射美托洛尔控制持续性心房颤动时快速心室率的临床评价(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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