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Title:: -

作者:: 余洋综述; 黄德嘉审校; 四川大学华西医院心血管内科，四川成都 610041

Author(s):: -

关键词:: 孤儿G蛋白偶联受体; APJ受体; Apelin

Keywords:: -

分类号:: Q26

DOI:: -

文献标识码:: A

摘要:: G蛋白偶联受体（GPCRs）是膜受体最大的一个家族，参与了广泛的生理和病理过程。孤儿GPCRs（oGPCRs）是一类内源性配基未定、功能未知的GPCRs。APJ受体（APJr）是一个古老的oGPCR，它与血管紧张素Ⅱ受体1（AT1R）有同源性，但是它不与血管紧张素Ⅱ（angⅡ）结合。其配基Apelin于1998年发现，被认为在体内具有重要的生理功能。ApelinAPJr有望成为临床上新的治疗靶点。

Abstract:: -

参考文献/References

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［2］ Chen MM, Ashley EA, Deng DXF, et al. Novel role for the potent endogenous inotrope Apelin in human cardiac dysfunction［J］. Circulation, 2003, 108(12): 1432-1439.

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［4］ Cheng X, Cheng XS, Pang CC. Venous dilator effect of Apelin, an endogenous peptide ligand for orphan APJ receptor, in conscious rats［J］. Eur J Pharmacol, 2003,470(3): 171-175.

［5］ Katugampola SD, Maguire JJ, Matthewson SR, et al. ［125I］(Pyr1)Apelin13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man［J］. Br J Pharmacol, 2001, 132(6): 1255-1260.

［6］ Szokodi I, Tavi P, Foldes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility［J］. Circ Res, 2002,91(5): 434-440.

［7］ Foldes G, Horkay F, Szokodi I, et al. Circulating and cardiac levels of Apelin,the novel ligand of the orphan receptor APJ, in patients with heart failure［J］. Biochem Biophys Res Commun, 2003,308(3): 480-485.

［8］ Zou MX, Liu HY, Haraguchi Y, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV) ［J］. FEBS Lett, 2000,473(1): 15-18.

［9］ Esposito V, De Falco M, De Luca L, et al. Immunohistochemical study of Apelin, the natural ligand of receptor APJ, in a case of AIDSrelated cachexia［J］. In Vivo, 2002,16(5): 337-340.

［10］Horiuchi Y, Fujii T, Kamimura Y, et al. The endogenous, immunologically active peptide Apelin inhibits lymphocytic cholinergic activity during immunological responses［J］. J Neuroimmunol, 2003, 144(1-2): 46-52.

［11］Reaux A, De Mota N, Skultetyova I, et al. Physiological role of a novel neuropeptide, Apelin, and its receptor in the rat brain［J］. J Neuroch,2001, 77(4): 1085-1096.

［12］Taheri S, Murphy K, Cohen M, et al. The effects of centrally administered Apelin13 on food intake, water intake and pituitary hormone release in rats［J］. Biochem Biophys Res Commu, 2002, 291(5): 1208-1212.

［13］o′Shea M, Hansen MJ, Tatemoto K, et al. Inhibitory effect of Apelin12 on nocturnal food intake in the rat［J］. Nutr Neurosc, 2003,6(3): 163-167.

［14］Sunter D, Hewson AK, Dickson SL, et al. Intracerebroventricular injection of Apelin13 reduces food intake in the rat［J］. Neurosci Lett, 2003, 353(1): 1-4.

［15］Wang GY, Anini Y, Wei W, et al. Apelin, a new enteric peptide, localization in the gastrointestinal Tract, ontogeny, stimulation of gastric cell proliferation and of cholecystokinin secretion［J］. Endocrinology, 2004,145:1342-1348.

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