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［4］ Goddard J, Johnston NR, Hand MF, et al. EndothelinA receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade［J］. Circulation， 2004，109: 1186-1193.

［5］ Chatziantoniou C, Dussaule JC. Endothelin and renal vascular fibrosis: of mice and men［J］. Curr Opin Nephrol Hypertens， 2000，9: 31-36.

［6］ Cecioni I, Modesti PA, Poggesi L, et al. Endothelin1 urinary excretion, but not endothelin1 plasma concentration, is increased in renovascular hypertension［J］. J Lab Clin Med，1999，134:386-391.

［7］ Kirilov G, Tomova A, Dakovska L, et al. Elevated plasma endothelin as additional cardiovascular risk factor in patients with Cushing′s syndrome［J］. Eur J Endocrinol，2003，149: 549-553.

［8］ Rossi GP, Ganzaroli C, Cesari M, et al. Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and hightonormal renin hypertension［J］. Cardiovasc Res，2003，57: 277-283.

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［14］ Pu Q, Neves MF, Virdis A, et al. Endothelin antagonism on aldosteroneinduced oxidative stress and vascular remodeling［J］. Hypertension，2003，42: 49-55.

［15］ Jougasaki M, Schirger JA, Simari RD, et al. Autocrine role for the endothelinB receptor in the secretion of adrenomedullin［J］. Hypertension，1998,32: 917-922.

［16］林丽，袁文俊. 内皮素1与心肌电活动、心肌缺血的关系［J］.心脏杂志，2000，12（5）：398-400.

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