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Title:: Correlation between AGT gene M235T polymorphism and essential hypertension from Xinjiang Kazakhs

作者:: 王笑峰¹; 刘艳²; 汪师贞²; 林仁勇²; 张丽萍²; 金力¹; 温浩²; 1.复旦大学生命科学学院遗传学研究所, 上海 200433；2.新疆医科大学第一附属医院中心实验室,新疆乌鲁木齐 830054

Author(s):: WANG Xiao-feng¹; LIU Yan²; WANG Shi-zhen²; LIN Ren-yong²; ZHANG Li-ping²; JIN Li¹; WEN Hao²; 1.State Key Laboratory, Genetic Engineering Center for Anthropological Studies, Fudan University, Shanghai 200433, China； 2.Cental Laboratory, First Teaching Hospital, Xinjiang Medical University, Urumqi，Xinjiang 830054, China

关键词:: 哈萨克族; 高血压; 血管紧张素原; 基因

Keywords:: Kazakh; hypertension; angiotensinogen; gene

分类号:: R544.1

DOI:: -

文献标识码:: A

摘要:: 目的探讨新疆哈萨克族血管紧张素原（angiotensinogen，AGT）基因第二外显子（M235T）多态性同高血压病（essential hypertension,EH）的关系。方法4次高血压流行病学调查采集新疆巴里坤哈萨克族EH组278例，正常血压（normaltensive, NT）组220例。测定EH患者和NT者体质量指数（BMI）、空腹血糖、血浆胆固醇、甘油三酯。用MSPCR法（mutagenically separated polymerase chain reaction technique ）检测AGT基因M235T多态性。结果M235T多态性符合HardyWeinberg平衡。MT 、TT 、MM 基因型分布频率在EH组及NT组分别为32.7%，62.6%，4.7%；38.2%，51.8%，10.0%。T等位基因频率分别为79.0% 及 70.9%。M235T基因型频率（P<0.05）及等位基因频率（P<0.01）分布在EH组及NT组均有显著性差异。T等位基因携带者OR值为非T等位基因携带者OR值的2.3倍（95%CI 1.1~4.6；P<0.05）。对未治疗的EH者在不同基因型间进行比较，未发现MT、MM、TT基因型间收缩压、舒张压、体质量指数、血糖、血脂水平有显著性差异。结论AGT基因M235T可能同新疆哈萨克族高血压病发病相关。

Abstract:: AIM To investigate the relationship between M235T polymorphism in angiotensinogen (AGT) gene and essential hypertension (EH) in Kazakhs in Xingjiang. METHODS A casecontrol study was performed in 278 hypertensive and 220 normaltensive (NT) Kazakh subjects, who were randomly selected from Barkol pasture. A previous medical history of diabetes and hypertension, and body mass index (BMI) were recorded. Fasting plasma glucose, triglyceride and cholesterol were measured. The variants M235T of AGT gene were determined using a mutagenically separated polymerase chain reaction (MSPCR) technique. RESULTS The distributions of M235T genotypes were MT (32.7%), TT (62.6%) and MM (4.7%) in hypertensive subjects and MT (38.2%), TT (51.8%) and MM (10.0%) in normotensive subjects. The frequency of T allele was 79.0% in hypertensive subjects and 70.9% in normotensive subjects. There were significant differences in both genotype distribution and allele frequencies between hypertensive and normotensive subjects. Odds ratios for EH of T allele was 2.3 times of nonT alleles, (OR TT+MT vs MM, 2.3; 95% CI 1.1-4.6; P<0.05). Further analyses found no significant correlation between M235T genotypes and age, BMI, Glu, triglyceride, cholesterol, systolic blood pressure (BP) and diastolic BP. CONCLUSION The T235 allele of the AGT gene may be related to the risk for EH in Kazakh population in Xinjiang.

参考文献/References

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［4］陈鹏，江艳芬，程康. 中国原发性高血压患者血管紧张素原M235T 多态性Meta 分析［J］. 中华流行病学杂志，2003，24(8)：711-714.

［5］卓玛次仁,庄兰平,崔超英,等. 藏族原发性高血压的遗传学研究［J］. 中华医学杂志，2002，82(15)：1009-1012.

［6］Pereira AC,Mota GF,Cunha RS,et al. Angiotensinogen 235T allele “Dosage” is associated with blood pressure phenotypes［J］. Hypertension,2003,41(1):25-30.

［7］Brand E, Chatelain N, Paillard F, et al. Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregationlinkage analysis［J］. Eur J Hum Genet, 2002, 10(11):715-723.

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AGT基因M235T多态同哈萨克族高血压病的关联分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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