我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

曲尼司特对心肌梗死后心肌间质纤维化的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第3期
页码:
326-328
栏目:
临床研究
出版日期:
2006-06-25

文章信息/Info

Title:
Tranilast inhibits myocardial fibrosis after myocardial infarction
作者:
方志成1王玮1周昌娥2郝朗损3谢永林4
郧阳医学院附属十堰市太和医院:1.心内科 , 2.肾内科 ,3.普外科, 4.超声影像科, 湖北 十堰 442000
Author(s):
FANG Zhi-cheng WANG WeiZHOU Chang-eHAO Lang-sunXIE Yong-lin
Department of Cardiology,Taihe Hospital,Yunyang University of Medicine, Shiyan,Hubei 442000,China
关键词:
曲尼司特心肌梗塞心室重构
Keywords:
tranilast myocardial infarction ventricular remodeling
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 探讨曲尼司特对兔心肌梗死后心肌间质纤维化干预作用。方法 结扎左前降支制作兔心肌梗死模型,分实验组和对照组。3周后经胃管分别给予曲尼司特及安慰剂1月,心脏彩超评价心功能并检测血清转化生长因子(transforming growth factor,TGFβ1),I、III型胶原浓度及组织羟脯胺酸含量。结果 实验组治疗前后心功能、心腔内径、室壁厚度明显改善,血清TGFβ1,I、III型胶原浓度及羟脯胺酸含量较对照组明显下降。结论 曲尼司特可有效拮抗心肌梗死后心肌间质纤维化,预防心室重构。
Abstract:
AIM To explore the effect of tranilast on the myocardial fibrosis after myocardial infarction. METHODS The model of myocardial infarction was made on rabbits by ligation of the major ventricular branch of the left coronary artery. Three weeks later, the rabbits were given tranilast or placebo for one month via gastric canal. Heart function was assessed and the levels of TGFβ1, collagen and hydroxyproline were measured. RESULTS Compared with the control, cardiac function, the bore of left ventricule, the concentration of TGFβ1, collagen and hydroxyproline were significantly decreased in tranilast group. CONCLUSION Tranilast effectively inhibis myocardial fibrosis after myocardial infarction and prevents the development of ventricular remodeling.

参考文献/References

[1] Ishiwata S, Verheye S, Robinson K, et al. Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation[J].J Am Coll Cardiol,2000,35(5) :1331-1337.

[2] Ohlstein E, Romanic A, Clark L, et al.Application of in vivo and ex vivo magnetic resonance imaging for evaluation of tranilast on neointima formation following balloon angioplasty of the rat carotid artery[J].Cardiovasc Res, 2000,47 (4) :759-768.

[3] Berthold H, Michael G, Jan O, et al.Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension[J] .J Hypertens,2002,20 (4) :745-751.

[4] Keiji M,Juichi F,Keiko M,et al.Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[J].Atherosclerosis,1996,121(2):167-173.

[5] Shojiro I,Uichi I,Tatsuya I,et al. Tranilast inhibits contraction and Ca2+ movement of procine coronary arteries[J].Atherosclerosis,1997,130(1-2):113-119.

[6] 黄荣杰,刘唐威,庞玉生, 等.转化生长因子β1在扩张型心肌病大鼠心肌纤维化中的作用[J].心脏杂志,2005,17(2):126-129.

[7] Pinto YM, PintoSietsma S, Philipp T, et al. Reduction in left ventricular messenger RNA for transforming growth factor β1 attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR (mRen 2) 27Rat [J].Hypertension,2000,36 (5) :747-754.

[8] Haruysi Y,Shingo T,Takeji N,et al.Tranilast inhibits collagen synthesis in normal,scleroderma and keloid fibroblasts at a late passage culture but not at a early passage culture[J].J Dermatol Sci, 1995,9(1):45-47.

[9] Fioa C,Alex T,Hey K, et al.Tranilast inhibits pathological collagen deposition,independent of haemodynamic alteration,following myocardial infarction in the rat[J]. Heart Lung and Circulation,2003,12(2):A39.

[10]Michal R,Takayki S,Alex A,et al.Inhibitory effects of tranilast on expression of transforming growth factor-isoforms and receptors in injured arteries[J].Atherosclerosis,1998,137(2):267-275.

[11]纪彩霓,胡义珍,丁正平,等.曲尼司特对青光眼患者体外培养的眼部Tenon囊成纤维细胞增殖和移行的影响[J].中华眼科杂志,2004,40(3):165-169.

备注/Memo

备注/Memo:
收稿日期:2005-04-04.作者简介:方志成,主治医师,硕士生 Tel:(0719)8896607 Email:fang5280@yahoo.com.cn
更新日期/Last Update: