文章摘要

文章信息/Info

Title:: Effect of clopidogrel treatment in patients with noSTelevation myocardial infarction

作者:: 英海蓉; 赵月; 李永超; 阜新市中心医院心内科，辽宁阜新 123000

Author(s):: YING Hai-rong; ZHAO Yue; LI Yong-chao; Department of Cardiology, Fuxin Central Hospital, Fuxin, Liaoning 123000, China

关键词:: 氯吡格雷; 非ST段抬高的心肌梗塞; 心血管事件

Keywords:: clopidogrel; no-ST-elevation myocardial infarction; cardiovascular events

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的评价联合应用氯吡格雷治疗非ST段抬高的心肌梗死的疗效。方法 60名诊断为急性非ST段抬高的心肌梗死患者随机分为3组，标准治疗组（对照组）、联合氯吡格雷1个月组（1个月组）、联合氯吡格雷6个月组（6个月组），观察指标为半年内发生的心血管事件。结果对照组13名（65%）、1个月组6名（30%）、6个月组1名（5%）发生心血管事件。1月组分别与对照组，6月组比较均P<0.05。结论标准治疗联合应用氯吡格雷治疗急性非ST段抬高的心肌梗死，可有效地预防心血管事件，而且联合应用6个月比1个月治疗效果更明显。

Abstract:: AIM To evaluate the efficacy and safety of clopidogrel in the treatment of noSTelevation myocardial infarction (NSTEMI). METHODS Sixty patients who were diagnosed as acute NSTEMI were randomly divided into 3 groups: standard treatment group (Control group), 1 month combined treatment of clopidogrel group (1 month group) and 6 month combined treatment of clopidogrel group ( 6 month group). In the followingup, all the cardiovascular events were recorded. RESULTS Thirteen patients in control group were found to have cardiovascular events, 6 patients in 1 month group and 1 patient in 6 month group. The difference between 1 month group and control group and that between 1 month group and 6 month group were significant (P<0.05). CONCLUSION Cardiovascular events can be prevented efficiently by using clopidogrel plus standard treatment in patients with NSTEMI and 6 month treatment is more efficient than 3 month treatment.

参考文献/References

［1］ Richardson P D, Davies M J, Born G V. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques［J］. Lancet ，1989，21，2(8669):941-944.

［2］ Furman M I,Benoit S E,Barnard M R,et al. Increased platelet reactivity and circulating monocyteplatelet aggregates in patients with stable coronary artery disease［J］. J Am Coll Cardiol, 1998，31(2):352-358.

［3］ Mitka M. Results of CURE trial for acute coronary syndrome［J］. JAMA,2001,285(14):1828-1829.

［4］ Karnon J, Bakhai A, Brennan A. et al. A costutility analysis of clopidogrel in patients with nonSTsegmentelevation acute coronary syndromes in the UK［J］. Int J Cardiol,2005，［Epub ahead of print］.

我们的网站为什么显示成这样？

氯吡格雷治疗非ST段抬高的心肌梗死疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

文章信息/Info

参考文献/References

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics