文章摘要

文章信息/Info

Title:: Establishment and assessment of rat model of heart failure after myocardial infarction

作者:: 田颖¹; 王江¹; 李振魁²; 祝善俊¹; 聂凌¹; 宋熔¹; 1．第三军医大学新桥医院心内科，重庆 400037；2.兰州军区总院心内科,甘肃兰州 730070

Author(s):: TIAN Ying; WANG Jiang; LI Zhen-kui; ZHU Shan-jun; NIE Ling; SONG Rong; Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

关键词:: 动物模型; 大鼠; 心肌梗塞; 心力衰竭; 血流动力学; 存活率

Keywords:: animal model; rat; myocardial infaction; heart failure; hemodynamic; survival rate

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的建立大鼠心肌梗死后心力衰竭(心衰)模型，并进行评估，以提高存活率和成功率。方法分批对160只大鼠行冠状动脉左前降支结扎手术，同时设48只假手术组，计算死亡率。在4周时行血流动力学检查，检测心率(HR)、左心室舒张末压(LVEDP)、计算左室压力最大上升速率(+dp/dtmax)和左室压力最大下降速率(-dp/dtmax)。结果 4周时模型组心率、+dp/dtmax和-dp/dtmax绝对值均低于假手术组(分别为P<0.05,P<0.01，P<0.01)，LVEDP则高于假术组(P<0.01)。随着手术大鼠例数的增多，存活率得到提高（P<0.05）。结论心梗后4周形成心衰模型，通过采取必要的措施，可以提高动物生存率。

Abstract:: AIM To establish and assess the rat model of heart failure after myocardial infaction (MI) to improve survival rate. METHODS The rat model of MI was made through ligating the anteriordescending coronary artery in 160 rats. The sham group was the same as MI group but without ligating the coronary artery. Hemodynamic parameters including heart rate, left ventricular end diastolic pressure (LVEDP), maximal velocity increase of pressure per second ( +dp/dtmax）and maximal velocity decrease of pressure per second (-dp/dtmax）were observed at 4th week and the mortality was evaluated. RESULTS At 4th week, HR, absolute value of +dp/dtmax and -dp/dtmax in model group were higher than those in sham group (P<0.05, P<0.01 and P<0.01). The survival rate was significantly improved from the first batch of rats to the last (P<0.05). CONCLUSION The heart failure model forms at 4th week after MI. The survival rate can improve with proper measures taken during and after the operation.

参考文献/References

［1］ Fisbein MC, Melecan D, Marko PR. Experimental myocardial infarction in the rat：qualitative and quantitative changes during pathologic evolution［J］. Am J Pathol, 1978,90（1）:57-70.

［2］Pfeffer MA, Pfeffer JM, Fisbein MC, et al. Myocardial infarct and ventricular function in rats［J］. Circ Res, 1979,44(4):503-512.

［3］王国印,周宜轩.心怡滴丸对实验性大鼠急性心肌梗死的影响［J］.心脏杂志, 2003,15(6):516-518.

［4］Li M, Zheng C, Sato T, et al. Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats［J］. Circulation, 2004,109(1): 120-124.

［5］Jayasankar V, Woo YJ, Bish LT, et al. Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure［J］. Circulation,2003,108 (Suppl 1): II230-II236.

［6］Omerovic E, Bollano E, Soussi B, et al. Selective beta1blockade attenuates postinfarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure［J］. Eur J Heart Fail,2003,5(6): 725-732.

我们的网站为什么显示成这样？

大鼠心肌梗死后心力衰竭模型的建立和评估(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

文章信息/Info

参考文献/References

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics