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急性心肌梗死时G-CSF的抗心肌重构及对心功能改善的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
509-512
栏目:
基础研究
出版日期:
2006-10-25

文章信息/Info

Title:
G-CSF improves heart function by supression of myocardial remodeling in acute myocardium infarction
作者:
于玲范;  刘文华; 姜雪松;  王晓旭; 张淑云; 刘伟
哈尔滨医科大学附属第二医院心脏监护中心， 黑龙江 哈尔滨 150086
Author(s):
YU Ling-fan;  LIU Wen-hua;  JIANG Xue-song;  WANG Xiao-xu; ZHANG Shu-yun; Liu Wei
Department of Cardiac Surgery Monitoring Centre， Second Clinical College, Harbin Medical University, Heilongjiang, Harbin 150086, China
关键词:
心肌梗塞; 粒细胞集落刺激因子; 动员; 心肌重构
Keywords:
myocardium infarction;  granulocyte colonystimulating factor;  mobilization;  myocardial remodelling
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 探讨急性心肌梗死（AMI）时动员剂粒细胞集落刺激因子（Granulocyte colonystimulating factor, GCSF）抗心肌重构和功能保护作用。方法 日本大耳白兔40只，随机分成两组，每组20只，均结扎冠状动脉前降支建立心肌梗死模型，动员剂组于模型建立后1 h给予GCSF皮下注射连续7 d，对照组系建立心肌梗死模型后仅注射生理盐水。术前、术后24 h及术后4周做心脏超声检测心功能，4周后处死动物，取出心脏行组织病理学分析，测定两组梗死面积的大小、毛细血管密度以及观察纤维化的情况。结果 动员剂组心功能各项指标在术后4周时均较对照组有明显的改善。HE染色显示对照组心肌纤维排列紊乱不规则，而动员剂组排列有序，梗死灶较对照组明显减小，且毛细血管密度也显著增加。胶原纤维明显少于对照组。结论 急性心肌梗死时给予GCSF可有效增加梗死区及周围毛细血管密度，缩小梗死面积，稳定心脏结构及显著改善心功能。
Abstract:
AIM To study the effects of Granulocyte colonystimulating factor (G-CSF) on myocardial remodeling and cardiac function in acute myocardial infarction (MI). METHODS MI was induced in 40 Japanese bigear white rabbits by ligating the anterior descending coronary artery. The rabbits were randomly divided into two groups: the vehicle control group receiving saline and the G-CSF group given hypodermic injection of GCSF 1 h after MI for 7 d. Echocardiography was performed 24 h before MI and 24 h, 4 wk after MI. The rabbits were sacrificed at 4 wk and histopathological analysis was made. RESULTS The G-CSF group showed better cardiac function than the control at 4 wk. HE staining showed that more orderly orientated myocardial fibers and reduced infarct size in the GCSF treated group than in the control group. G-CSF treatment also resulted in neogenesis of capillaries and reduced amount of blue collagen fibers as reflected by Masson staining. CONCLUSION The results suggest that G-CSF treatment improves cardiac function by reducing infarct size, increasing neogenesis of capillaries and suppression of myocardial remodelling.

参考文献/References

［1］ Ramakrishnan S, Kothari SS, Bahl VK. Stem cells and myocardial regeneration［J］. IHJ, 2003,55(2):119-124.

［2］ Takano H, Ohtsuka M, Akazawa H, et al. Pleiotropic effects of cytokines on acute myocardial infarction: GCSF as a novel therapy for acute myocardial infarction［J］. Curr Pharm Des, 2003,9(14):1121-1127.

［3］ Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infracted heart, improving function and survival［J］. Proc Natl Sci USA, 2001, 98(18):10344-10349.

［4］ Norol F, Merlet P, Isnard R, et al. Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model［J］. Blood，2003,102(13):4361-4368.

［5］ Winter JN, Lazarus HM, Rademaker A, et al. Phase Ⅰ/Ⅱ study of combined granulocyte colonystimulating factor and granulocytemacrophage colonystimulating factor administration for the mobilization of hematopoietic progenitor cells［J］. J Clin Oncol, 1996,14(1):177-186.

备注/Memo

备注/Memo:
收稿日期：2004-12-12.基金项目：黑龙江省教育厅海外学会项目资助(No.74817256)黑龙江省科技攻关项目资助（No.GC04C30103）作者简介：于玲范，主任医师 Tel：（0451）86414999 Email:yulingfan@163.com
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