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甲状腺机能亢进大鼠腹主动脉与股动脉血管反应性的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
516-519，527
栏目:
基础研究
出版日期:
2006-10-25

文章信息/Info

Title:
Alterations in arterial responsiveness of abdominal aorta and femoral artery in hyperthyroid rats
作者:
张子泰1; 侯英萍1; 邓敬兰1; 暴军香2; 汪静1; 宋武战1; 马进2
第四军医大学：1.西京医院核医学科，2.航空航天生理学教研室，陕西 西安 710032
Author(s):
ZHANG Zi-tai1;  HOU Ying-ping1;  DENG Jing-lan1;  BAO Jun-xiang2;  WANG Jing1;  SONG Wu-zhan1;  MA Jin2
1.Department of Nuclear Medicine, Xijing Hospital, 2.Department of Aerospace Physiology, Fourth Military Medical University, Xi′an,Shaanxi 710032, China
关键词:
甲状腺机能亢进; 左旋甲状腺素; 动脉反应性; 大鼠
Keywords:
hyperthyoidism;  L-thyroxine;  arterial responsiveness;  rat
分类号:
R338;R581.1
DOI:
-
文献标识码:
A
摘要:
目的 观察甲状腺机能亢进时大鼠大动脉和中等动脉离体血管环收缩反应性和舒张反应性的变化，以探讨甲亢时动脉反应性变化对外周循环的影响。方法 采用左旋甲状腺素（左旋T4，优甲乐）胃饲大鼠25 d建立甲亢大鼠模型。24只雄性SD大鼠(体质量350 ~400 g)随机分为3组（每组8只）：对照组，甲亢1组［(低剂量组, 左旋T4，0.3 mg/(kg·d)］，甲亢2组［(高剂量组, 左旋T4，0.6 mg/(kg·d)］，使用离体动脉环测定腹主动脉和股动脉血管的反应性。结果 甲亢组和对照组相比，由氯化钾（1~9）×10-2 mol/L和苯肾上腺素（10-9 mol/L~10-4 mol/L)激发的两种动脉血管的收缩反应显著降低（P<0.05）；由乙酰胆碱（10-9 mol/L~ 10-4 mol/L)和硝普钠（10-9 mol/L~10-4 mol/L)引起的舒张反应则显著增强（P<0.05）。甲亢组大鼠的腹主动脉与股动脉对氯化钾、乙酰胆碱和硝普钠反应的敏感性增强，而对苯肾上腺素反应的敏感性减弱。结论 甲亢大鼠腹主动脉和股动脉的血管收缩反应性降低，而舒张反应性增强。
Abstract:
AIM To investigate the alterations in arterial contractile and dilatory responsiveness of abdominal aorta and femoral artery in hyperthyroid rats. METHODS To induce hyperthyroidism, Levothyroxine (LT4, Euthyrox) was used to feed rats for 25 days by intragastric administration. Twentyfour male SpragueDawley rats weighing 350-400 g were randomly divided into three groups (n=8/group): control group, hyperthyroidism1 group ［(lowdose group, LT4, 0.3 mg/(kg·d)］ and hyperthyroidism2 group ［(highdose group, LT4, 0.6 mg/(kg·d)］. Arterial ring preparations from both abdominal aorta and femoral artery were used to determine their contractile and dilatory responses to various agents. RESULTS Compared with those in control group, contractile responses in both abdominal aortic and femoral arterial rings evoked by both KCl （1-9）×10-2 mol/L and phenylephrine (PE, 10-9 mol/L-10-4 mol/L) significantly decreased（P<0.05）in hyperthyroid rats. But dilatory responses of 0.5 μmol/L PE preconstricted rings induced by acetylcholine （10-9 mol/L-10-4 mol/L) and sodium nitroprusside （10-9 mol/L-10-4 mol/L) significantly increased（P<0.05） in both abdominal aortic and femoral arterial rings of hyperthyroid rats. The sensitivity of both abdominal aorta and femoral artery to KCl, ACh and SNP were significantly enhanced by hyperthyroid state, but EC50 of both abdominal aortic and femoral arterial rings to PE increased in hyperthyroid rats. CONCLUSION Contractile responsiveness is decreased and dilatory responsiveness is enhanced in abdominal aorta and femoral artery of hyperthyroid rats.

参考文献/References

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［8］ 徐健,林汉华. 葡萄糖转运子2在不同甲状腺功能状态大鼠肝脏中的变化［J］. 中华内分泌代谢杂志,2004,20(2):172-173.

［9］ 马进，任新玲，程九华，等. 模拟失重大鼠去内皮股动脉血管反应性的变化［J］. 中华航空航天医学杂志,2003,14(4)：200-203.

备注/Memo

备注/Memo:
收稿日期：2005-12-26.基金项目：第四军医大学后备人才基金项目资助（No.4138A4307） 通讯作者：马进，副教授，主要从事心血管生理学研究Tel：（029）84774809 Email：jinma@fmmu.edu.cn. 作者简介：张子泰，主治医师，硕士生 Tel:（029）84773147 Email：zztwlh@tom.com.
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