我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

心脏手术患者尿微量蛋白水平变化及抑肽酶对它的干扰(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
568-569，573
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
Interference of aprotinin on urinary microprotein level in patients undergoing heart operation
作者:
伍长学; 肖锡俊; 袁宏声
四川大学华西医院胸外科，四川 成都 610041
Author(s):
WU Chang-xue;  XIAO Xi-jun;  YUAN Hong-sheng
Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu，Sichuan 610041, China
关键词:
抑肽酶; 微量蛋白; 肾损害;  干扰
Keywords:
aprotinin;  microprotein;  renal damage;  interference
分类号:
R605
DOI:
-
文献标识码:
A
摘要:
目的 观察抑肽酶对心脏手术患者尿微量蛋白水平的干扰。方法 选择心脏手术患者40例，随机分为抑肽酶组和对照组，比较两组患者术后尿微量蛋白水平。结果 术后尿白蛋白（Alb）、免疫球蛋白G （IgG）和α-微球蛋白（α-MG），尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)水平均高于术前，而血液BUN、Cr水平没有显著变化。术后抑肽酶组尿Alb、 IgG、α-MG显著高于对照组，而两组间NAG、BUN、Cr并没有统计学差异。结论 尿Alb、 IgG、α-MG、 NAG能反映早期肾损害，但尿Alb、 IgG、α-MG容易受抑肽酶干扰, 因此不适合监测心脏手术患者肾损害。
Abstract:
AIM To investigate the interference of aprotinin on the urinary microprotein level in patients undergoing heart operation. METHODS Forty patients undergoing heart operation were randomly divided into two groups: aprotinin group (n=20) and control group (n=20). The level of urinary microprotein was detected and compared. RESULTS The levels of urinary albumin (Alb), immunoglobulin, (IgG), α-microglobulin (α-MG) and N-acetyl-β-D-glucosaminidase (NAG) were significantly higher than those preoperation, but no difference of blood urinary nitrogen (BUN) and blood creatine (Cr) was found compared with those preoperation. The levels of urinary Alb, IgG and α-MG of patients in aprotinin group were significantly higher than those of control group, but no difference of NAG, BUN and BCr were found between the two groups . CONCLUSION Urinary Alb, IgG, α-MG and NAG can reflect the earlier period renal damage, but urinary Alb, IgG and α-MG are interfered by aprotinin. Therefore urinary microproteins are not reliable indexes for the observation of renal damage in patients undergoing heart operation.

参考文献/References

［1］ Amico G, Bazzi C . Urinary protein and enzyme excretion as markers of tubular damage［J］. Curr Opin Nephrol Hypertens,2003，12(6): 639-643.

［2］ Smith MS. Antifibrinolytic agents make alphaland Beta2microglobulinuria poor markers of post cardiac surgery renal dysfunction［J］. Anesthesiology, 1999,90(3): 928-929.

［3］ Boldt J, Brenner T， Lang J, et al. Kidneyspecific proteins in elderly patients undergoing cardiac surgery with cardiopulmonary bypass［J］. Anesth Analg, 2003,97(6): 1582-1589.

［4］ Han K, Bonventre J. Biologic markers for the early detection of acute kidney injury［J］. Curr Opin Critical Care, 2004,10(6): 476-482.

［5］ Abid O, Sun Q, Sugimoto K, et al. Predictive value of microalbuminuria in medical ICU patients: results of a pilot study［J］. Chest, 2001,120(6) :1984-1988.

［6］ Bazzi C, Petrini C, Rizza V, et al. Urinary excretion of IgG and alpha(1)microglubulin predicts clinical course better than extent of proteinuria in membranous nephropathy［J］. Am J Kidney Dis， 2001,38(2):240-248.

［7］ 于海波，韩雅玲，高柏青，等. 替米沙坦改善原发性高血压病患者心肌肥厚及早期肾功能失调［J］.心脏杂志，2005，17（1）：39-41.

［8］ 李桂珍，魏广丽. 尿微量蛋白含量变化与糖尿病肾病的早期诊断［J］.放射免疫学杂志，2004，17（3）：204-205.

［9］ Greilich PE,Brouse CF,Rinder CS,et al. Effects of epsilonaminocaproic acid and aprotinin on leukocyteplatelet adhesion in patients undergoing cardiac surgery［J］. Anesthesiology，2004,100(2):225-233.

［10］黄惠民，丁文祥，苏肇伉，等. 心脏手术应用大剂量抑肽酶对肾功能的影响［J］. 中华胸心血管外科杂志，1994，10（1）：63.

［11］伍长学，肖锡俊，袁宏声，等 . 体外循环围术期尿NAG/Cr变化及乌司他丁对肾的保护作用［J］. 中国胸心血管外科临床杂志，2005，2（1）：61-62.

备注/Memo

备注/Memo:
收稿日期：2005-05-20.作者简介：伍长学，博士 Tel：（028）85457325 Email：Wuchangxue19@yahoo.com.cn
更新日期/Last Update: