我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

曲美他嗪治疗不稳定型心绞痛的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
666-667
栏目:
临床研究
出版日期:
2006-12-25

文章信息/Info

Title:
Curative effect of trimetazidine on patients with unstable angina pectoris
作者:
王群让1; 李丽2
陕西省核工业215医院:1.心内科,2.急诊科 ,陕西 咸阳 712000
Author(s):
WANG Qun-rang1;  LI Li2
1.Department of Cardiology, 2.Department of Emergency, 215 Hospital of Nuclear Industry of Shaanxi Province, Xianyang,Shaanxi 712000, China
关键词:
曲美他嗪; 心绞痛; 不稳定型; 疗效
Keywords:
trimetazidine; unstable angina pectoris;  effect
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察曲美他嗪治疗不稳定型心绞痛（UAP）的临床疗效和安全性。方法 74例UAP患者分为常规对照组和曲美他嗪治疗组，各37例。后者服用曲美他嗪20 mg,3次/d，余用药同对照组。观察两组治疗前后临床疗效，心电图及动态心电图变化，患者的药物耐受性，不良反应。结果 治疗后曲美他嗪组总疗效率86.5%，对照组总有效率62.2%，心电图改善率分别为72.9%和48.6%，动态心电图缺血发作次数、总缺血时间均有显著减少（P<0.05），且患者耐受性良好，无不良反应。结论 在常规治疗的基础上加用曲美他嗪能安全、更有效地控制UAP。
Abstract:
AIM To evaluate the effect and safety of trimetazidine in patients with unstable angina pectoris (UAP). METHODS Seventyfour patients with UAP were randomly divided into two groups: routine treatment group and routine plus trimetazidine group with 20 mg three times a day. and the results were compared. The curative effect and the changes of ECG, Holter, the tolerence and side effect to trimetazidine were compared before and after the treatment. RESULTS After the treatment, the rate of curative effect of trimetazidine treatment group was 86.5% while that of routine group was 62.2%. The improvement rate of ECG of two groups was 72.9% and 48.6%, respectively. Holter showed that the times of ischemia and the total time of ischemia of the trimetazidine group decreased significantly (P<0.05). The patients had good tolerance to trimetazidine and no obvious side effects were found. CONCLUSION On the basis of regular treatment, combined treatment of trimetazidine can more effectively control UAP.

参考文献/References

［1］ 黄洁，吴拥健，朱文青，等. 曲美他嗪治疗稳定劳力型心绞痛的双盲对照研究［J］.中国新药杂志，1999，8（8）：538-539.

［2］ Kantor P F, Lucien A, Kozak R, et al.The antianginal drug trmetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondril longchain 3ketoacyl coenzyme A thiolase ［J］ .Circ Res,2000，86(5):580-588.

［3］ Lavanchy N, Martin J, Rossi A . Antiischemic effects of trmetazidine :31PNMR spectroscopy in the isolated rat heart ［J］. Arch Int Pharmacodyn Ther, 1987,286(1):97-110.

［4］ Renaud JF. Internal pH ,Na+ and Ca2+ regulation by trimetaxidine during cardiac cell acidosis［J］. Cardiovasc Drugs Ther,1988,1(6):677-686.

［5］ Maupoil V, Rochette L,Tabard A, et al. Direat measurement of free radical generation in isolated rat heart by electron patamagnetic resonance spectroscopy : effect of trinetazidine ［J］. Adv Exp Med Biol,1990,264:373-376.

［6］ Williams FM, Tanda K, Kus M,et al. Trimetazidine inhibits meutrophil accumulation after myocardial ischemia and reperfusion in rabbits ［J］ . J Cardiovasc Pharmacol,1993,22(6):828-833.

［7］ 戴德银. 实用新特药手册［M］. 第3版. 北京:人民军医出版社,2003.561.

备注/Memo

备注/Memo:
收稿日期：2005-11-01.作者简介：王群让，主治医生 Tel：(0910)3577661 Email：wqr11111@sina
更新日期/Last Update: