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|本期目录/Table of Contents|

体外循环心脏术后抗凝血酶活性与手术不良结果的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
682-684
栏目:
临床研究
出版日期:
2006-12-25

文章信息/Info

Title:
Postoperative antithrombin levels and adverse outcome in cardiac operations
作者:
王红兵; 单飞; 崔勤; 胡晓旻; 刘松涛
第四军医大学西京医院心血管外科， 陕西 西安 710032
Author(s):
WANG Hong-bing;  SHAN Fei;  CUI Qin;  HU Xiao-min;  LIU Song-tao
Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi′an,Shaanxi 710032, China
关键词:
抗凝血酶; 体外循环; 心脏手术; 并发症
Keywords:
antithrombin;  cardiopulmonary bypass;  cardiac surgery;  complications
分类号:
R651.11
DOI:
-
文献标识码:
A
摘要:
目的 观察患者回到ICU后的抗凝血酶活性以及术后各种不良结果的联系。方法 2005年3月至5月在我科接受体外循环心脏手术的237例患者。分别测定术前、术后的抗凝血酶活性，并观察分析其与术后不良效应的相关性。结果 术后抗凝血酶活性较术前显著降低（P<0.01）。分析发现术后抗凝血酶的低活性与胸引量增多，机械通气时间延长以及ICU的天数，输血量增加，二次开胸，低心排，神经系统并发症，血栓栓塞，肾功能不全等明显相关。结论 ICU内患者抗凝血酶的低活性与心脏术后的预后不良相关；并且可以预示患者在ICU的时间将会延长。
Abstract:
AIM To investigate the association between antithrombin activity at admission to the ICU (ICUantithrombin activity) and various outcome variables. METHODS The subjects included in this study were 237 consecutive patients who had undergone cardiac surgery with cardiopulmonary bypass at our department. The antithrombin activity was measured pre and post operation and the association with outcome in cardiac surgery was observed. RESULTS ICUantithrombin activity significantly (P<0.01) decreased when compared with preoperative values. The statistics showed that low levels of ICUantithrombin activity were significantly associated with higher blood loss, prolonged mechanical ventilation time and ICU stay, a higher incidence of allogeneic blood products use, surgical reexploration, low cardiac output syndrome, adverse neurologic events, thromboembolic events, and renal dysfunction. CONCLUSION Low levels of ICUantithrombin activity are associated with a poor outcome in cardiac surgery. ICUantithrombin activity is predictive of prolonged ICU stay.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-09-20.作者简介：王红兵，副教授 Tel：（029）84771021 Email：hydtheing@tom.com
更新日期/Last Update: