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不稳定型心绞痛介入治疗前后vWF和GMP140的变化及临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第1期
页码:
48-50
栏目:
临床研究
出版日期:
2007-01-01

文章信息/Info

Title:
Clinical evaluation of changes of vWF and GMP140 in unstable angina pectoris cases after percutaneous coronary intervention
作者:
韩艳丽1; 王营1; 李继福2; 姜红菊1;  左岩霞2;  朱靖1;  王健1;  刘芳1; 纪求尚2
1.山东中医药大学第二附院心内科，山东 济南 250001;2.山东大学齐鲁医院心内科，山东 济南 250012
Author(s):
HAN Yanli;  ＷANG Ying;  LI Jifu;  JIANG Hongju;  ZUO Yanxia;  ZHU Jing;  WANG Jian;  LIU Fang;  JI Qiushang
Department of Cardiology,Second Affiliated Hospital, Chinese Medical University in Shandong, Jinan 250001,Shandong, China
关键词:
经皮冠状动脉介入治疗; 不稳定型心绞痛; 假性血友病因子; 血小板α颗粒蛋白
Keywords:
percutaneous coronary intervention; unstable angina pectoris;  von Willebrand factor;  alphagranule membrance protein 140
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨不稳定型心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)后假性血友病因子（vWF）和血小板α颗粒蛋白（GMP140）水平的变化规律及临床意义。方法 连续观察35例(A组)UAP患者PCI术前及术后1、24、72 h血液中vWF和GMP140的变化。另设单纯行冠脉造影的UAP患者30例（B组）和健康者30例（C组）作对照。vWF和GMP140分别用酶联免疫吸附双抗体夹心法测定血浆含量，并随访术后3个月心血管事件的发生情况。结果 vWF在A、B组的浓度显著高于C组（P<0.01﹚，A组介入治疗后1 h进一步升高，持续至24 h（P<0.05﹚，然后逐渐回落；B组术前与术后无显著改变。A、B组GMP140的浓度显著高于C组（P<0.05﹚，A组介入治疗后在1 h即达峰值(P<0.01)，然后迅速回落，72 h至术前水平；随访期内B组心血管事件发生率显著高于A组(57% vs 14%,P<0.01)。结论 UAP 患者介入治疗后vWF、GMP140在72 h内有动态变化，反映了PCI后冠脉内皮功能受损和血小板激活上述指标持续升高，可能是术后早期心血管事件的危险因素。
Abstract:
AIM To evaluate the changes and significances of von Willebrand Factor (vWF) and alphaGranule Membrance Protein 140 （GMP140）in unstable angina pectoris patients after percutaneous coronary intervention（PCI）. METHODS The changes of vWF and GMP140 were tested before and 1, 24 and 72 h after PCI in 35 unstable angina pectoris patients（A group）, 30 UAP patients （B group） who had undertaken coronary angiography and 30 normal subjects （C group）. All the UAP patients were followed up for 3 months. RESULTS The concentrations of vWF and GMP140 in UAP cases significantly increased compared with those in normal subjects（P<0.01, P<0.05﹚. The level of vWF reached its peak 24 h after PCI (P<0.05) and the level of GMP140 raised 1h after PCI(P<0.01) and dropped to that before PCI at 24 h ~72 h . The morbidity of vascular disease in group B was higher than that of group A after PCI (57% vs 14%,P<0.01). CONCLUSION The plasma level of vWF and GMP140 in UAP patients changes significantly after PCI. The damage of endothelium of coronary artery and the activation of platelets. The higher level of them in PCI 72 h might be responsible for the early clinical events.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-11-07.通讯作者：韩艳丽，副主任医师，硕士生，主要从事心脏介入治疗研究Email：hyl87255@sohu.com
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