我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

艾司洛尓和尼卡地平对围术期心肌缺血的保护效应(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
212-214
栏目:
临床研究
出版日期:
2007-04-01

文章信息/Info

Title:
Protective effect of Esmolol and Nicardipine on myocardial ischemia during preoperative period
作者:
梁琪1;  叶平安2
1.西安市中医医院麻醉科，陕西 西安 710001；2.西安交通大学第一医院麻醉科，陕西 西安 710061
Author(s):
LIANG Qi1;  YE Pingan2
1.Department of Anesthesiology, Xi′an Chinese Traditional Medicine Hospital, Xi′an 710001, Shaanxi, China; 2.Department of Anesthesiology, First Hospital, Xi′an Jiaotong University, Xi′an 710061, Shaanxi, China
关键词:
艾司洛尓; 尼卡地平; 心肌缺血; 心肌钙蛋白
Keywords:
esmolol;  nicardipine;  myocardial ischemia;  cardiac troponin
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 研究艾司洛尓和尼卡地平对围术期心肌缺血的保护效应。方法 60例ASA Ⅱ~Ⅲ级拟全麻下行择期非心脏手术的心肌缺血患者，随机分成实验组和对照组各30例。实验组在全麻诱导气管插管后给艾司洛尔40 μg/(kg·min)和尼卡地平1 μg/(kg·min)静注，对照组给予生理盐水。分别于麻醉前、诱导后和手术结束时监测ECG ST段下移幅度和血清cTnI浓度。结果 实验组和对照组于麻醉前和诱导后ST段下移幅度和血清cTnI值均无显著性差异。手术结束后，实验组ST段下移幅度和血清cTnI值较麻醉前无显著性差异，对照组ST段下移幅度和血清cTnI值较麻醉前显著增大（P<0.05）；组间ST段下移幅度和血清cTnI值有显著差异（P<0.05）。结论 艾司洛尓和尼卡地平对围术期心肌缺血具有保护效应。
Abstract:
AIM To investigate the protective effect of Esmolol and Nicardipine on myocardial ischemia during preoperative period. METHODS Sixty patients with myocardial ischemia undergoing selective noncardiac surgery were randomly divided into experimental group, who received Esmolol 40 μg/（kg·min） and Nicardipine 1 μg/（kg·min） after endotracheal intubation, and control group, who received normal saline as control. Downward shift distance of ECG ST section and serum cTnI value were monitored before anesthesia, after induction of anesthesia and at the end of the surgery. RESULTS In two groups, the downward shift distance of ECG ST section and serum cTnI value were not significantly different between before anesthesia and after induction of anesthesia . At the end of the surgery, in experimental group, the downward shift distance of ECG ST section and serum cTnI value were not significantly different compared with those before anesthesia . In control group, the downward shift distance of ECG ST section and serum cTnI value significantly increased compared with those before anesthesia (P<0.05). The downward shift distance of ECG ST section and serum cTnI value were significantly different between two groups (P<0.05). CONCLUSION Esmolol and Nicardipine exert some protective effect on myocardial ischemia during preoperative period.

参考文献/References

［1］ 徐启明.围术期心肌缺血及其处理［J］.中华麻醉学杂志,2001,21(3):191-192.

［2］ Thielmann M, Massoudy P, Neuhauser M, et al. Prognostic value of preoperative cardiac troponin I in patients undergoing emergency coronary artery bypass surgery with nonSTelevation or STelevation acute coronary syndromes［J］. Circulation, 2006, 114(1 Suppl):I448-I453.

［3］ 王忠诚,沈钧乐,王强. 心肌肌钙蛋白I 的检测方法及临床应用进展［J］. 国外医学·临床生物化学与检验学分册,2004,25(4): 303-305.

［4］ 张国楼,全麻插管期心血管副反应的防治［J］.临床麻醉学杂志,2001,17(12): 673.

［5］ Wartier DC, Pagel PS, Kersten JR. Approaches to the prevention of perioperative myocardial ischemia ［J］. Anesthesiology, 2000, 92(4):253-256.

［6］ 屠伟峰,戴建强.非心脏手术老年患者围术期心肌缺血的预测和防治［J］.临床麻醉学杂,2003,19(7):434-436.

［7］ 梁琪,叶平安. 高血压患者非心脏手术围术期心肌损伤及尼卡地平干预的研究［J］. 陕西医学杂志,2001,30(7):404-406.

［8］ 袁红斌,王新华.钙离子和钙通道阻滞剂对心血管的作用及其与临床麻醉的关系［J］.心脏杂志,2002,14(1):72-75.

备注/Memo

备注/Memo:
收稿日期：2006-09-18.作者简介：梁琪，主治医师，硕士Email:dawn@mail.xjtu.edu.cn
更新日期/Last Update: