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左旋卡尼汀对老年腹部术后心力衰竭患者的疗效分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第3期
页码:
326-328
栏目:
临床研究
出版日期:
2007-06-01

文章信息/Info

Title:
Clinical effect of Lcarnitine on postoperative congestive heart failure of elderly patients following abdominal operation
作者:
王蓉; 尚延忠; 李朝晖
解放军总医院南楼综合科，北京 100853
Author(s):
WANG Rong;  SHANG Yanzhong;  LI Zhaohui
South Wing, PLA General Hospital, Beijing 100853, China
关键词:
心力衰竭; 充血性;  左旋卡尼汀;  心功能
Keywords:
heart failure ;  congestive; Lcarnitine; heart function
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的 观察左旋卡尼汀治疗老年腹部术后心力衰竭患者的临床疗效。方法 选择腹部手术后并发心力衰竭老年患者57例, 随机分为2组，对照组25例予洋地黄、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂等常规药物治疗，卡尼汀组32例,在常规治疗的基础上加用国产左旋卡尼汀5.0 ｇ治疗15 d。结果 两组治疗后临床症状和射血分数（EF）较治疗前均有改善，但卡尼汀组心功能改善的临床显效率(44%)和总有效率(94%)均较对照组(36%和80%)显著提高(分别为P<0.05和Ｐ<0.01), 治疗后卡尼汀组EF（0.52±0.03）与对照组（0.50±0.04）和治疗前（0.48±0.05）相比，差别均有显著性意义（均P<0.01），且无药物不良反应。结论 左旋卡尼汀辅助治疗老年腹部术后心力衰竭患者有较好疗效。
Abstract:
AIM To evaluate the clinical effect of Lcarnitine (LCN) on postoperative congestive heart failure of elderly patients who had undergone abdominal operation. METHODS Fiftyseven elderly patients with postoperative congestive heart failure following abdominal operation were randomly divided into control group receiving conventional treatment (digitalis, diuretics, vasodilator, ACEI) and LCN group (conventional treatment combined with LCN). The treatment course was 15 days. RESULTS There was some difference in heart function changes in two groups before and after treatment. But the effective rate in improving heart function was 94% in L CN group and 80% in control group (P<0.01). Significant difference in left ventricular ejecting fraction was found between the two groups after treatment (P<0.05). No adverse effects of the drug were observed. CONCLUSION LCN combined with conventional treatment effectively improves the heart function when used to treat the postoperative congestive heart failure of elderly patients who have undergone abdominal operation.

参考文献/References

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［2］ Rizxos I. Three years survival of patients with heart failure caused by dilated cardiomyopathy and Lcarnitine administration［J］. Am Heart J，2000, 139(2 pt 3):S120-S123

［3］ 殷仁富,张治宇,时慧琦,等.左旋卡尼汀能有效提高稳定型心绞痛患者的运动耐量［J］.心脏杂志，2006,18(4):442-444.

［4］ Colonna P, Iliceto S. Myocardial infarction and left ventricular remodeling: result of the CEDIM trial. Carnitine Ecocardiografia Digitalizzata Infarto Miocardico ［J］. Am Heart J, 2000, 139(2 pt 3) : S124-S130.

［5］ 何勇,郑强荪,张录兴,等.左旋卡尼汀治疗慢性充血性心力衰竭的疗效观察［J］. 心脏杂志，2005,17(1):49-51.

［6］ 肖立中，江志平，黄志,等.左旋卡尼汀对冠心病慢性心力衰竭患者心功能的影响［J］.实用心脑肺血管病杂志，2004,12(1):1-3.

［7］ 陈旭昌,何勇,郑强荪,等.左旋卡尼汀治疗缺血性心脏病心力衰竭临床观察 ［J］.心脏杂志，2004,16(1):94.

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备注/Memo

备注/Memo:
收稿日期：2006-10-11. 作者简介：王蓉，主治医师，硕士 Email: wangrong9669@yahoo.com.cn
更新日期/Last Update: