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冠心病患者辅助性T细胞亚群的变化及意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
395-398
栏目:
基础研究
出版日期:
2007-08-01

文章信息/Info

Title:
Dynamic changes of Th1/Th2 subsets in coronary arterial disease
作者:
韩淑芳; 张薇; 布伦; 贾国良
第四军医大学西京医院心内科，陕西 西安 710032
Author(s):
HAN Shufang;  ZHANG Wei;  BU Lun;  JIA Guoliang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
动脉粥样硬化; 辅助性T细胞; 炎症反应
Keywords:
atherosclerosis;  T helper subsets;  inflammatory.
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 通过分析不同状态冠心病患者［稳定型心绞痛（SA)、不稳定型心绞痛(UA)、急性心肌梗死(AMI）］辅助性T细胞亚群（Th1/Th2）的变化，探讨辅助性T细胞在冠心病进程中的作用。方法 通过胞内细胞染色对45例不同状态冠心病患者及13例健康对照者的外周血单个核细胞（PBMC）进行Th1/Th2亚群分型，ELISA法检查患者血浆Th1/Th2相关细胞因子水平，分析患者Th1/Th2的变化。结果 ①UA及AMI组患者Th1亚群细胞较SA组及对照组显著扩增（P<0.01）；②各组之间Th2亚群细胞变化未见统计学意义；③Th1亚群相关细胞因子，IFNγ和IL2，在UA和AMI组显著升高（P<0.01）。Th2亚群相关细胞因子IL10在各组之间未见明显变化，IL4低于检测水平。结论 T细胞亚群（Th1/Th2）的失衡与冠心病斑块的激活密切相关，其相关细胞因子IFNγ和IL2的增加使系统炎症反应进一步恶化。
Abstract:
AIM To investigate the dynamic changes of Th1/Th1 subsets in different phases of coronary arterial disease. METHODS We investigated the peripheral IFNγ/CD3+T subsets and IL4/CD3+T subsets of patients with coronary arterial disease (CAD) and controls by flow cytometric analysis and T helper 1/T helper2 related cytokines by ELISA. RESULTS ①T helper 1 cells increased in unstable angina pectoris (UA) and AMI group compared with those in stable angina pectoris (SA) and controls; ②T helper 2 cells remained largely unchanged around the time of plaque destabilization; ③The levels of T helper 1 related cytokines, IFNγ and IL2 were higher in UA and AMI groups than those in SA and control groups. No difference was found in T helper 2 related cytokine, IL10 between the groups. CONCLUSION The expansion of T helper subsets is consistent with the advancement of vulnerable plaque. Th1 related cytokines, IFNγ and IL2, contribute to the acceleration of plaque destabilization.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-08-24.作者简介：韩淑芳，医师，博士生Email:tangchao@fmmu.edu.cn
更新日期/Last Update: