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冠心病患者冠状动脉病变与心率变异性的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第5期
页码:
578-581
栏目:
临床研究
出版日期:
2007-10-01

文章信息/Info

Title:
Correlation between heart rate variability and coronary artery pathology in patients with coronary artery disease
作者:
许宜冠1; 周胜华2; 李玉光1; 沈向前2; 胡信群2; 方臻飞2; 陈畅1; 许端敏1
1.汕头大学医学院第一附属医院心内科，广东 汕头 515041；2. 中南大学湘雅二医院心内科，湖南 长沙 410011
Author(s):
XU Yiguan1;  ZHOU Shenghua2;  LI Yuguang1;  SHEN Xiangqian2;  HU Xinqun2;  FANG Zhenfei2;  CHEN Shang1;  XU Duanmin1
1.Department of Cardiovasology, First Affiliated Hospital of Medical College of Shantou University, Shantou 515041， Guangdong, China; 2.Department of Cardiovasology Xiangya, Second Hospital, Central South University, Changsha 410011， Hunan, China
关键词:
冠状动脉疾病; 冠状动脉病变; 心率变异性; 时域指标
Keywords:
coronary disease; coronary artery pathology; heart rate variability; timedomain analysis
分类号:
R541.4；R540.4+1
DOI:
-
文献标识码:
A
摘要:
目的 了解冠心病患者冠状动脉病变与心率变异性（HRV）的关系。方法 回顾性分析111例患者冠状动脉造影及24小时动态心电图检查资料，按冠状动脉造影结果分为3组：冠状动脉造影完全正常（正常组）、至少有一支冠状动脉狭窄 >50% （狭窄组）、至少有一支冠状动脉完全阻塞（闭塞组）；通过动态心电图检查分析HRV的时域指标：SDNN、SDANNind、SDNNind、rMSSD、PNN50。结果 ① 随冠状动脉狭窄程度加重，SDNN、SDANNind、SDNNind逐渐下降，完全阻塞组这些指标下降最显著；② 随冠状动脉病变支数增加，SDNN、SDANNind、SDNNind、rMSSD、PNN50有进一步下降趋势，但只有3支病变HRV下降才有统计学意义；③ 左冠状动脉病变SDNN、SDANNind显著下降，而右冠状动脉病变下降不显著。 结论 冠心病患者HRV显著下降提示冠状动脉狭窄程度重、病变范围广、病变在左冠状动脉。
Abstract:
AIM To study the correlation between the heart rate variability (HRV) and the coronary artery pathology in patients with coronary artery disease (CAD). METHODS One hundred and eleven patients who had had coronary angiography (CAG) and 24 h ECG Holter record were retrospectively studied. The subjects were classified into three groups according to coronary artery pathology in CAG: no abnormality in all coronary artery (n=43), narrowing >50% (n=43) and total occlusion (n=25) at least in one of coronary artery. In each subject, a 24 h ECG Holter tape had been recorded and subsequently analyzed to obtain timedomain HRV ( SDNN, SDANNind, SDNNind, Rmssd, PNN50). RESULTS ①SDNN, SDANNind and SDNNind lowered with the degree of coronary narrowing and were the lowest in subjects with total occlusion. ② SDNN, SDANNind, SDNNind, rMSSD and PNN50 tended to be lower with the increasing number of coronary artery abnormality. But the change was significant only in subjects who had abnormality in all the three coronary arteries. ③ SDNN and SDANNind were significantly lower in subjects with left coronary artery abnormality but not in those with right coronary artery abnormality. CONCLUSION The findings that HRV is significantly lower in patients with coronary artery disease indicate that patients with CAD may have total occlusion in one of the coronary arteries, severe narrowing in all the three coronary arteries and severe narrowing in the left coronary artery.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-04-17.作者简介：许宜冠，主治医生，博士Email:guanxy111222@hotmail.com
更新日期/Last Update: