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盐酸乌拉地尔和多巴酚丁胺联用治疗慢性充血性心力衰竭的临床观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第6期
页码:
667-668/674
栏目:
临床研究
出版日期:
2007-12-20

文章信息/Info

Title:
Clinical observation on combined use of Urapidil and Dobutamine in treatment of chronic congestive heart failure
作者:
孙慧灵; 张琳
郑州市中心医院心内三科，河南 郑州 450007
Author(s):
SUN Hui-ling;  ZHANG Lin
Zhengzhou Central Hospita, Zhengzhou 450007, Henan, China
关键词:
乌拉地尔; 多巴酚丁胺; 心力衰竭; 充血性
Keywords:
urapidil; dobutamine; congestive heart failure
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的 观察盐酸乌拉地尔和多巴酚丁胺治疗慢性充血性心力衰竭（CHF）的临床疗效。方法 将62例心功能（NYHA）Ⅲ~Ⅳ级的CHF患者，随机分为乌拉地尔治疗组和硝普钠对照组各31例。在常规加多巴酚丁胺治疗的基础上，治疗组给予乌拉地尔25~100 mg泵入；对照组给予硝普钠25~50 mg泵入。 结果 两组治疗后心功能均有改善，乌拉地尔组有效率97％，硝普钠组有效率100％；两组用药后血压、心率、呼吸均明显下降，左室射血分数（LVEF）分别为(46±6)%（P<0.01）和(46±5)%（P<0.01）。两组均未见明显不良反应。结论 盐酸乌拉地尔和多巴酚丁胺联合治疗CHF疗效确切，安全可靠。
Abstract:
AIM To observe the clinical therapeutic efficacy of Urapidil combined with Dobutamine in the treatment of chronic congestive heart failure. METHODS Sixtytwo chronic congestive heart failure patients with cardiac function (NYHA) Ⅲ-Ⅳ were randomly divided into the treatment group (n=31) and the control group (n=31). All patients were treated with routine drugs and dobutamine . Patients in treatment group were treated with Urapidil 25-100 mg and those in control group were treated with Nipruton 25-50 mg . RESULTS The improvement of cardiac function was observed in both treatment group (LVEF 46%±6%, P<0.01) and control group (LVEF 46%±5%, P<0.01 ) . The effective rate of the treatment group was 97% and that of the control group was 100%. No untoward reaction was detected. CONCLUSION Urapidil combined with Dobutamine has obvious therapeutic effects and is safe in the treatment of patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-12-12.作者简介：孙慧灵，主治医师 Email：shlys2007@163.com
更新日期/Last Update: