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作者:: 王江; 田颖; 祝善俊; 第三军医大学新桥医院全军心血管内科中心，重庆 400037

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关键词:: 血管紧张素转换酶2; 血管紧张素1-7; 心力衰竭

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分类号:: R543

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文献标识码:: A

摘要:: 血管紧张素转换酶2（ACE2）是2000年才发现的肾素血管紧张素系统的新成员，主要表达于心脏、肾脏和睾丸。ACE2的主要生物学效应是降解血管紧张素II（Ang II）产生Ang 1-7，Ang 1-7具有舒张血管、抗增生、抗炎症的作用，对衰竭心脏有保护作用。研究发现ACE2基因敲除小鼠心功能受损，Ang II水平升高。本文综述了ACE2的生物学效应以及在心血管系统中的意义。

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参考文献/References

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血管紧张素转换酶2在心血管系统中的意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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