我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

芪丹通脉片对急性心肌梗死家兔心肌肌钙蛋白I的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第4期
页码:
398-402
栏目:
基础研究
出版日期:
2008-08-20

文章信息/Info

Title:
Effect of qidantongmai Tablet on cardiac troponin I of acute myocardial infarction in rabbits
作者:
肖茜1; 王宗仁1; 王超2; 彭道荣3; 马静1; 陈金钟1; 李晶华1
第四军医大学: 1.西京医院中医科,2.药物研究所,3.西京医院检验科,陕西 西安 710032
Author(s):
XIAO Qian1;  WANG Zongren1;  WANG Chao2;  PENG Daorong3;  MA Jing1;  CHEN Jinzhong1;  LI Jinghua1
1.Department of Traditional Chinese Medicine, Xijing Hospital, 2.Institute of Materia Medica, Department of Pharmacy, 3.Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
芪丹通脉片; 结扎冠状动脉; 心肌梗死; 家兔; 肌钙蛋白
Keywords:
qidantongmai tablet;  deligation coronary artery;  myocardial infarction;  rabbit;  cardiac troponin
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 观察芪丹通脉片(QDTMT)对结扎冠状动脉所致家兔心肌梗死后肌钙蛋白I的变化,探讨QDTMT作用于心肌梗死的机制。方法 采用结扎冠状动脉左旋支致家兔心肌梗死模型,观察灌胃给药14 d后QDTMP对心肌梗死的预防作用。结果 ①模型组家兔出现明显的心肌梗死,QDTMT各组心肌梗死程度与模型组比较,其病变程度显著减轻(P<001)，心肌梗死面积缩小(P<001)。②光镜和电镜观察可见QDTMT能明显减轻家兔心肌病理损伤,改善心肌细胞超微结构。③心肌梗死后肌钙蛋白I升高,用QDTMT组肌钙蛋白I明显降低,用药组与模型组比较有显著差异(P<0.05或P<001)。结论 QDTMT对家兔结扎冠状动脉所致心肌梗死损伤具有明显的保护作用。
Abstract:
AIM To observe the effect of qidantongmai Tablet (QDTMT) on the changes of cardiac troponin I in rabbits following their death caused by ligationinduced acute myocardial infarction (AMI) and its mechanism. METHODS We observed the preventive effects of QDTMT on AMI after a 14day intrgastric QDTMT administration in the model of coronary artery left circumflex ligationinduced acute myocardial infarction. RESULTS ①Obvious myocardial infarction was found in the model group but myocardial infarction in QDTMT groups alleviated significantly (P<001) and the infarction area shrunk (P<001). ②Light microscope and electron microscope showed that QDTMT significantly reduced pathological injury in myocardium and improved the ultramicrostructure of cells. ③The content of cTnI significantly decreased in QDTMT groups, significantly different from that in the model group (P<005 or P<001). CONCLUSION QDTMT has obvious protective effect on myocardium in rabbits with ligationinduced acute myocardial infarction.

参考文献/References

[1] 彭毅,陈宏础. 缺血性心肌损伤实验室诊断进展[J]. 现代诊断与治疗, 2000, 11(1):30-32.

[2] Bhayana V, Henderson AR. Biochemical markers of myocardial damage[J]. Clin Biochem, 1995, 28(1):1-29.

[3] Jenkins DP, Pugsley WB, Alkhulaifi AM, et al. Ischemic preconditioning reduces troponin T release in patients undergoing coronary artery by pass surgery[J]. Heart, 1997, 77(4):314-318.

[4] Zaninotto M, Altinier S, Lachin M, et al. Strategies for the early diagnosis of acute myocardial infarction using biochemical markers[J]. Am J Clin Pathol, 1999, 111(3):399-405.

[5] Lofberg M, Tahtela R, Harkonen M, et al. Myosin heavy chain fragments and cardiac troponin in the serum in rhabdomyolysis diagnostic specificity of new biochemical markers[J]. Arch Neural, 1995, 52(12):1210-1214.

[6] Wu AH, Lane PL. Meta analysis in clinical chemistries: validation of cardiac troponin T as a marker for ischemic heart diseases[J]. Clin Chem, 1995, 41(8 Pt 2):1228-1233.

[7] 韦建瑞. 心肌肌钙蛋白I的检测在临床心肌损伤中的应用[J]. 岭南心血管病杂志, 1999, 5（特刊）:52.

[8] 宋玉胜,吕元. 心肌肌钙蛋白I: 心肌损伤的敏感性和特异性指标[J]. 中国实验诊断学, 1998, 2(2):93.

[9] Barton PJ, Cullen ME, Townsend PJ, et al. Close physical linkage of human troponin genes organization, sequence, and expression of the locus encoding cardiac troponin Ⅰ and slow skeletal troponin T[J]. Genomics, 1999, 57(1):102-109.

[10]李晶华,王宗仁,邵中军,等. 芪丹通脉片对实验性急性心肌梗死大鼠心肌的保护作用及其分子机制\[J\]. 中国临床康复, 2004, 8(9):1706-1707.

[11]Bers DM. Cardiac excitationcontraction coupling[J]. Nature, 2002, 415(6868):198-205.

备注/Memo

备注/Memo:
收稿日期：2008-02-08.基金项目：军队“十一五”中医药研发重大临床攻关课题项目资助（2006191001） 通讯作者：王宗仁，主任医师,主要从事心脑血管瘀症研究Email:zongren@fmmu.edu.cn 作者简介：肖茜,硕士生Email:xq_718@163.com
更新日期/Last Update: