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β2肾上腺素能受体基因Arg16/Gly的多态性与新疆哈萨克族男性左室肥厚的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第5期
页码:
570-573,583
栏目:
临床研究
出版日期:
2008-10-20

文章信息/Info

Title:
Correlativity between β2adrenergic receptor gene +46 Arg16/Gly polymorphism and left ventricular hypertrophy in males of Kazakh nationality in Xinjiang
作者:
彭宇明1; 2; 李涛2; 骆秦2; 左君丽2; 周玲2; 李南方2
1.新疆医科大学研究生学院，新疆 乌鲁木齐 830054； 2.新疆自治区人民医院高血压科，新疆 乌鲁木齐 830001
Author(s):
PENG Yuming1; 2;  LI Tao2;  LUO Qin2;  ZUO Junli2;  ZHOU Ling2;  LI Nanfang2
1.Graduate College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uigur Autonomous Region, China; 2.Institute of Hypertension, People’s Hospital, Urumqi 830001, Xinjiang Uigur Autonomous Region, China
关键词:
β2 肾上腺素能受体; 基因多态性; 左室肥厚; 哈萨克族; 男性
Keywords:
β2adrenergic receptor;  single nucleotide polymorphisms;  left ventricular hypertrophy;  Kazakh nationality
分类号:
Q577
DOI:
-
文献标识码:
A
摘要:
目的 探讨β2肾上腺素能受体(β2-adrenergic receptor,ADRβ2)基因+46 A→G(Arg16/Gly)的多态性在哈萨克族男性左室肥厚(LVH)发生中的作用。方法 采集191例20～69岁哈萨克族人的遗传标本,采用聚合酶链反应-限制性酶切片段长度多态性(PCR-RFLP)技术分析ADRβ2基因+46 A→G的多态性。根据心电图的结果，将所有样本分为LVH组及非LVH组，观察各基因型和等位基因的分布频率与LVH的关系。 结果 哈萨克族男性LVH组与非LVH组间基因型频率的分布存在统计学差异(P<0.05)。进一步用logistic回归模型扣除年龄、血压的影响后,显示携带GG基因型的个体发生LVH的风险为AA基因型个体的0.475倍。 结论 ADRβ2 基因+46 A→G基因的多态性与哈萨克族男性LVH相关,GG基因型可能是哈萨克族男性LVH发生的保护性因子。
Abstract:
AIM To investigate the relationship between polymorphism of β2Adrenergic receptor (ADRβ2) gene +46 A→G Arg16/Gly and left ventricular hypertrophy (LVH) in males of Kazakh nationality in Xinjiang. METHODS A total of 191 males of Kazakhs nationality aged from 20 to 69subjects were divided into two groups according to absence or presence of LVH determined by electrocardiography. The genotypes of ADRβ2 gene Arg16/Gly variant were detected by the polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) technique and its distribution and relationship to LVH were investigated. RESULTS Significant differences in genotypes distributions were found between LVH and nonLVH groups (P<0.05), though no significant differences of allele frequencies distribution were seen between the two groups. After adjustment age and blood pressure by logistic regression model, the LVH risk of the individuals with GG genotype was 0.475 folds compared with the that of individuals with AA homozygote genotype. CONCLUSION Polymorphism of ADRβ2 gene Arg16/Gly is associated with LVH of males of Kazakh nationality and the GG genotype may be the protective factor of LVH.

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备注/Memo

备注/Memo:
收稿日期：2007-12-18.基金项目:国家自然科学基金项目资助(30260038)；自治区科技攻关和重点科技项目资助（200633129） 通讯作者：李南方，主任医师,主要从事高血压的临床、分子生物学及流行病学研究Email:Lnanfang@yahoo.com.cn 作者简介：彭宇明，主治医师Email:pyming119@163.com
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