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Title:: Serum profiles of circulating granulocytemacrophage colonystimulating factor after acute myocardial infarction and its relation with ventricular function

作者:: 付真彦; 马依彤; 杨毅宁; 黄定; 艾尔肯; 张建发; 刘芬; 新疆医科大学第一附属医院心血管研究中心，新疆乌鲁木齐 830054

Author(s):: FU Zhenyan; MA Yitong; YANG Yining; HUANG Ding; AI Erken; ZHANG Jianfa; LIU Fen; Cardiovascular Research Center, First Affiliated Hospital, Xinjiang Medical University, Urumchi 830054, Xinjiang, China

关键词:: 粒细胞-巨噬细胞集落刺激因子; 心肌梗死; 急性; 心肌重构

Keywords:: GM-CSF; acute myocardial infarction; remolding

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的研究急性心肌梗死(AMI)后患者血清粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平变化，及其与心功能的关系。方法 AMI患者30例，AMI后8，16，24，36，48 h及3，4，5，6，7 d分别测定血清GM-CSF,肌酸激酶同工酶(CK-MB) 浓度。并在AMI 1周后测量左室射血分数(LVEF)，左室舒张末期内径(LVEDD)。从30例患者中选取5例急性广泛前壁心梗，并且LVEF<40％的患者作为亚组，描述心梗后GMCSF时间相；并分析30例患者血清GMCSF峰值与心梗后心功能的关系。结果 GM-CSF在AMI后8 h开始逐渐升高，36～72 h达高峰，在以后7 d的测量中均保持较高水平。GM-CSF峰值与CK-MB峰值呈正相关(r=0.566,P<0.05)；与LVEF呈负相关(r=-0.42,P<0.05)；与LVEDD呈正相关(r=0.454,P<0.05)。结论心肌梗死后血清GMCSF水平增高与心功能呈负相关。

Abstract:: AIM To investigate the kinetics of granulocytemacrophage colonystimulating factor (GM-CSF) in the serum of patients with acute myocardial infarction (AMI) and its relation with postinfarction ventricular function. METHODS Serum levels of GM-CSF and creatine kinase isoenzyme (CK-MB) were determined serially in 30 AMI patients (after AMI 8 h, 16 h, 24 h, 36 h, 48 h, 3 d, 4 d, 5 d, 6 d, 7 d). Left ventricular ejection fraction (LVEF) and left ventricular enddiastolic dimension (LVEDD) were determined one week after AMI. Out of the 30 patients, 5 patients with extensive anterior wall infarction, LVEF<40% formed a subgroup to describe the graph of GM-CSF. The relation between the peak level of GM-CSF and ventricular function were also explored in the 30 patients. RESULTS Serum GM-CSF activities increased at<8 h and peaked at 36-72 h after the attack, remaining elevated >7 days. Significant correlations were observed between the peak of GM-CSF levels and the peak of serum CK-MB (r=0.566, P<0.05) and between the peak GM-CSF levels and LVEF (r=-0.42, P<0.05), LVEDD (r=0.454, P<0.05). CONCLUSION GM-CSF elevates during the course of AMI and is negatively correlated with left ventricular function.

参考文献/References

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［8］ Terrovitis J, Charitos C, Dolou P, et al. No effect of stem cell mobilization with GMCSF on infarct size and left ventricular function in experimental acute myocardial infarction［J］. Basic Res Cardiol, 2004, 99(4):241-246.

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急性心肌梗死后血清GM-CSF水平变化及其与心功能的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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