我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

诱导骨髓间充质干细胞向心肌细胞分化 及相关信号通路的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第5期
页码:
634-637
栏目:
综述
出版日期:
2008-10-20

文章信息/Info

Title:
-
作者:
曾俊义1; 魏云峰1; 汪泱2
南昌大学第一附属医院: 1.心血管内科,2.泌尿外科研究所，江西 南昌 330006
Author(s):
-
关键词:
骨髓间充质干细胞; 诱导分化; 信号通路
Keywords:
-
分类号:
R329.2
DOI:
-
文献标识码:
A
摘要:
骨髓间充质干细胞具有自我更新、增殖及多向分化的特点，在体外可通过5氮胞苷、共培养等多种途径诱导分化为心肌样细胞。相关研究表明， Notch、Wnt等信号通路在这一过程中发挥着重要作用。
Abstract:
-

参考文献/References

［1］ 张近宝，顾春虎，刘维水，等. 犬骨髓间充质干细胞可诱导分化为组织工程瓣间质种子细胞［J］. 心脏杂志， 2006， 18（5）：489-491,495.
［2］ 徐瑾，王彬尧，王长谦，等. 骨髓间充质干细胞在心肌梗死区的移植和分化对心肌梗死后心力衰竭的影响［J］. 心脏杂志， 2006， 18（2）：138-142.
［3］ 王月刚，吴平生. 干细胞移植治疗冠心病的应用进展［J］. 心脏杂志， 2007， 19（1）：91-95.
［4］ 王莹，龚卫琴，张珊红，等. 骨髓间充质干细胞不同移植方法对心肌梗死大鼠心脏的保护作用［J］. 心脏杂志， 2007， 19（3）：266-268.
［5］ Xu W, Zhang X, Qian H, et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro［J］. Exp Biol Med, 2004, 299(7):623-631.
［6］ 程芮，王士雯，曹丰，等. 5氮胞苷浓度对体外骨髓间充质干细胞诱导分化为心肌样细胞的影响［J］. 中华老年多器官疾病杂志， 2005， 4（3）：196-220.
［7］ Shim WS, Jiang S, Wong P, et al. Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocytelike cells［J］. Biochem Biophys Res Commun, 2004, 324(2):481-488.
［8］ Price MJ, Chou CC, Frantzen M, et al. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties［J］. Int J Cardiol, 2006, 111(2):231-239.
［9］ Xu M, Wani M, Dai YS, et al. Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes［J］. Circulation, 2004, 110(17):2658-2665.
［10］Yoon J, Shim WJ, Ro YM, et al. Transdifferentiation of mesenchymal stem cells into cardiomyocytes by direct celltocell contact with neonatal cardiomyocyte but not adult cardiomyocytes［J］. Ann Hematol, 2005, 84(11):715-721.
［11］Li H, Yu B, Zhang Y, et al. Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes［J］. Biochem Biophys Res Commun, 2006, 341(2):320-325.
［12］Anversa P, Kajstura J, Leri A, et al. Life and death of cardiac stem cells: a paradigm shift in cardiac biology［J］. Circulation, 2006, 113(11):1451-1463.
［13］Yamashita JK, Takano M, HiraokaKanie M, et al. Prospective identification of cardiac progenitors by a novel single cellbased cardiomyocyte induction［J］. FASEB J, 2005, 19(11):1534-1536.
［14］Matsuura K, Nagai T, Nishigaki N, et al. Adult Cardiac Sca1positive cells differentiate into beating cardiomyocytes［J］. J Biol Chem, 2004, 297(12):11384-11391.
［15］Fazel S, Cimini M, Chen L, et al. Cardioprotective ckit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines［J］. J Clin Invest, 2006, 116(7):1865-1877.
［16］Yuasa S, Itabashi Y, Koshimizu U, et al. Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells［J］. Nat Biotechnol, 2005, 23(5):607-611.
［17］van Wijk B,Moorman AF, van den Hoff MJ.Role of bone morphogenetic proteins in cardiac differentiation［J］. Cardiovasc Res, 2007, 74(2):244-255.
［18］Wang J, WynshawBoris A. The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation［J］. Curr Opin Genet Dev, 2004, 14(5):533-539.
［19］Kühl M. The WNT/calcium pathway: biochemical mediators,tools and future requirements［J］. Front Biosci, 2004, 9:967-974.
［20］Terami H, Hidaka K, Katsumata T, et al. Wnt11 facilitates embryonic stem cell differentiation to Nkx25positive cardiomyocytes［J］. Biochem Biophys Res Commun, 2004, 325(3):968-975.
［21］Koyanagi M, Haendeler J, Badorff C, et al. Noncanonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells［J］. J Biol Chem, 2005, 280(17):16838-16842.
［22］Singh AM, Li FQ, Hamazaki T, et al. Chibby,an antagonist of the Wnt/βCatenin pathway,facilitates cardiomyocyte differentiation of murine embryonic stem cells［J］. Circulation, 2007, 115(5):617-626.
［23］RosenblattVelin N, Lepore MG, Cartoni C, et al. FGF2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes［J］. J Clin Invest, 2005, 115(7):1724-1733.
［24］Song H, Kwon K, Lim S, et al. Transfection of nesenchymal stem cells with the FGF2 gene improves their survival under hypoxic conditions［J］. Mol Cells, 2005, 19(3):402-407.
［25］Kruithof BP, van Wijk B, Somi S, et al. BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage［J］. Dev Biol, 2006, 295(2):507-522.
［26］Marguerie A, Bajolle F, Zaffran S, et al. Congenital heart defects in Fgfr2IIIb and Fgf10 mutant mice［J］. Cardiovasc Res, 2006, 71(1):50-60.
［27］Chau MD, Tuft R, Fogarty K, et al. Notch signaling plays a key role in cardiac cell differentiation［J］. Mech Dev, 2006, 123(8):626-640.
［28］Nemir M, Croquelois A, Pedrazzini T, et al. Induction of cardiogenesis in embryonic stem cells via downregulation of notch1 signaling［J］. Circ Res, 2006, 98(12):1471-1478.

备注/Memo

备注/Memo:
收稿日期：2007-08-13.基金项目：江西省自然基金项目资助（0640189） 通讯作者:魏云峰,教授,主要从事干细胞与缺血性心肌病方面 的研究Email:zjy2005052@163.com 作者简介：曾俊义,硕士生Email:zjy2005052@163.com
更新日期/Last Update: