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|本期目录/Table of Contents|

急性冠脉综合征中CD40L 和基质金属蛋白酶致病作用的研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
63-65
栏目:
临床研究
出版日期:
2009-02-28

文章信息/Info

Title:
Role of CD40L and matrix metalloproteinses in pathogenesis of acute coronary syndrome
作者:
张庆成1; 侯燕2; 张向峰1; 汪承炜1
1.武警上海总队医院心血管内科,上海 201103；2.上海市普陀区老年病医院内科,上海 200062
Author(s):
ZHANG Qing-cheng1;  HOU-Yan2;  ZHANG Xiang-feng1;  WANG Cheng-wei1
1.Department of Cardiology, Shanghai Corps Hospital, Chinese People’s Armed Police Forces, Shanghai 201103, China; 2.Department of Internal Medicine, Putuo Distric Geriatric Hospital, Shanghai 200062, China
关键词:
急性冠脉综合征; CD40配体; 基质金属蛋白酶; 致病作用
Keywords:
acute coronary syudrome;  CD40L;  matrix metalloproteinses;  pathogenesis
分类号:
R543.32；Q559
DOI:
-
文献标识码:
A
摘要:
目的 探讨CD40L和基质金属蛋白酶（MMP）在冠脉斑块形成中的作用机制。方法 对59例冠状动脉造影证实，有冠状动脉狭窄的急性冠脉综合症患者（男31例，女28例，平均年龄60.3岁），分为不稳定型心绞痛组（n=32）、急性心肌梗死组（n=27），同时设正常对照组（体检健康者，n=30）。采用ELISA法检测血清CD40L、C反应性蛋白（CRP）、MMP-2和MMP-9的水平。结果 与正常对照组比较，血清CD40L、CRP、MMP-2和MMP-9的水平，随病情的加重而升高且差异显著（P<0.01），多支病变者的水平高于单支病变者。血清MMP-2与MMP-9的水平、CD40L与MMP-9的水平均呈正相关（r值分别为0.71和0.78）。结论 血清MMP-2和MMP-9水平的增高与冠脉斑块的形成有一定的联系。CD40L可能是通过MMP-s引起冠脉损伤，从而导致斑块形成和冠心病的发生发展。
Abstract:
AIM To explore the role of serum CD40L and matrix metalloproteinses（MMP-s） levels in coronary plague formation. METHODS Fifty-nine (31 men and 28 women, mean age 60.3 years) acute coronary syndrome patients with coronary stenosis confirmed by coronary arteriography were divided into acute myocardial infarction (AMI) group (n=27) and unstable angina pectoris (UAP) group (n=32), and a normal control group (n=30) was set up. The levels of serum CD40L, MMP-2 and MMP-9 were detected by ELISA. RESULTS Compared with those in normal control group, the levels of serum CD40L, MMP-2 and MMP-9 were significantly elevated along with exacerbation of the disease (P<0.01) and the levels of serum CD40L, MMP-2 and MMP-9 in the patients with multiple coronary lesions were higher than those in the patients with single coronary lesion. The levels of serum CD40L, MMP-2 and MMP-9 were positively correlated with that of CD40L (r=0.71 and 0.78, respectively). CONCLUSION The elevation of serum CD40L, MMP-2 and MMP-9 levels are to some extent related to the coronary plague formation. CD40L may cause coronary lesion by way of MMP-s, thus leading to the coronary plague formation and the development of coronary diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-1-10.作者简介：张庆成，副主任医师，博士 Email:summit＿ZXF@yahoo.com.cn
更新日期/Last Update: 2009-04-02