维尔亚和依那普利对原发性高血压患者心电图P波离散度的影响
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2009年第1期
- 页码:
- 76-78
- 栏目:
- 临床研究
- 出版日期:
- 2009-02-28
文章信息/Info
- Title:
- Effects of candesartan and enalapril on p wave dispersion in patients with essential hypertension
- Author(s):
- LI Yong-qin; WANG Min; FAN Yan-mei; WANG Rong; QIN xiao-jin
- Department of Cardiology, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China
- Keywords:
- p wave dispersion; hypertension; essential; atrial fibrillation
- 分类号:
- R544.1
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 观察血管紧张素Ⅱ受体拮抗剂和血管紧张素转化酶抑制剂对原发性高血压（EH）患者心电图P波时限和离散度的影响。方法 EH患者68例，随机分为两组，维尔亚4 mg/d和依那普利10 mg/d，血压控制不良者可加用利尿剂和钙离子拮抗剂，共观察6个月。分别于用药前后测定12导联体表心电图中P波时限和P波离散度。结果 用药后两组均可使EH患者心电图P波时限和P波离散度减小，组间比较显示，维尔亚组的作用更优于依那普利组。结论 维尔亚对EH患者心电图P波时限和P波离散度的作用强于依那普利。
- Abstract:
- AIM To study the different effects of angiotensin Ⅱ type Ⅰ receptor antagonist and angiotensin conversion enzyme inhibitor on the p wave dispersion in eletrocardiography in patients with essential hypertension. METHODS Forty-eight patients were divided into two groups randomly: one group was treated with candesartan 4 mg/d while the other group with enalapril 10 mg/d totally for 6 months respectively and the p wave duration and p wave dispersion were analyzed before and after the treatment. RESULTS After the treatment, the p wave duration and p wave dispersion in both groups of patients with essential hypertension decreased (P<0.05). Candesartan had more obvious effect on p wave dispersion compared with that of enalapril. CONCLUSION Candesartan is more effective than enalapril in preventing atrial fibrillation in patients with essential hypertension.
参考文献/References
[1］ Dilaveris PE, Gialafos EJ, Chrissos D, et al. Detection of hypertensive patients at risk for paroxysmal atrial fibrillation during sinus rhythm by computer-assisted P wave analysis［J］. J Hypertens, 1999, 17(10):1463-1470.［2］ Nakashima H, Kumagai K, Urata H, et al. Angiotensin Ⅱ antagonist prevents electrical remodeling in atrial fibrillation［J］. Circulation, 2000, 101(22):2612-2617.［3］ Madrid AH, Bueno MG, Rebollo JM, et al. Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation.:aprospective and randomized study［J］. Circulation, 2002, 106(3):331-336.［4］ Lopez B, Querejeta R, Varo N, et al. Usefulness of cardioreparative ability of antihypertensive treatment in hypertensive patients［J］. Circulation, 2001, 104(3):286-291.［5］ Mitchell AR, Spurrell PA, Sulke N. Circadian variation of arrhythmia onset patterns in patients with persistent atrial fibrillation［J］. Am Heart J, 2003, 146(5):902-907.［6］ Ciaroni S, Cuenoud L, Bloch A. Clinical study to investigate the predictive parameters for the onset of atrial fibrillation in patients with essential hypertension［J］. Am Heart J, 2000, 139(5):814-819.
备注/Memo
- 备注/Memo:
- 收稿日期：2007-12-27.作者简介：李永勤，主治医师，博士Email：wsxlyq@163.com
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