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|本期目录/Table of Contents|

中医络风内动证血管内超声的病变特征

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
88-91
栏目:
临床研究
出版日期:
2009-02-28

文章信息/Info

Title:
Lesion characteristics evaluated by intravascular ultrasound in patients with endogenous collateral wind
作者:
王显; 胡大一; 沙鸥
北京军区总医院心血管内科，北京 100700
Author(s):
WANG Xian;  HU Da-yi;  SHA Ou
Department of Cardiology, General Hospital， Beijing Military Area Command, Beijing 100700, China
关键词:
冠状动脉疾病; 血瘀证; 络风内动证; 血管内超声; 冠状动脉重构
Keywords:
coronary artery disease;  blood stasis;  endogenous collateral wind;  intravascular ultrasound;  the arterial remodeling
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 比较冠心病不同中医证型的血管内超声（IVUS）特征。方法 选择做血管内超声（IVUS）检查的冠心病患者28例，按中医辨证分为血瘀证组（n=10）和络风内动证组(n=18)。采用IVUS测定两组“罪犯”病变斑块面积、外弹力膜（EEM）面积、斑块负荷、高危斑块发生率、正向重构、负向重构和重构指数（RI）等指标，使用SPSS11.0软件包，对比分析两组资料。结果 络风内动证组“罪犯”病变处的斑块面积、EEM面积和斑块负荷均显著大于血瘀证组（分别P<0.01，P<0.01和P<0.05），高危斑块发生率和重构指数（RI）也明显高于血瘀证组（均P<0.05）；正重构更常见于络风内动证组（P<0.05），负重构常见于血瘀证组（P<0.05）。结论 络风内动证组患者冠状动脉粥样硬化斑块破裂的可能性更高。
Abstract:
AIM To compare the lesion characteristics measured by intravascular ultrasound (IVUS) in different types of syndrome by traditional Chinese medicine in patients of coronary artery diseases. METHODS Twendty-eight consecutive patients of coronary artery disease confirmed by IVUS was made the differential diagnosis as blood stasis group (n=10) and endogenous collateral wind group (n=18). The indexes such as area of plaques in criminal lesions, the area of extra-elasticity membrane (EEM), plaque burden, the incidence of high-risk plaques, the positive or negative remodeling percentage and remodeling index (RI) were measured by IVUS. Analyses were performed by statistical package SPSS11.0. RESULTS The area of plaques in criminal lesions, the area of EEM and plaque burden in endogenous collateral wind group were significantly larger than those in blood stasis group (P<0.01, P<0.01, P<0.05, respectively). The incidence of high-risk plaques and RI in endogenous collateral wind group were markedly higher than those in blood stasis group (P<0.05, P<0.05, respectively). More positive remodeling was observed in endogenous collateral wind group (P<0.05) whild the more negative remodeling was seen in blood stasis group (P<0.05). CONCLUSION The coronary arterial atherosclerotic plaques in the patients with endogenous collateral wind may be more unstable.

参考文献/References

[1］ 王显,杨巨成. 急性冠脉综合征“络风内动”假说及实践［J］. 中华中医药杂志, 2002, 17(9):19-22.
［2］ 王显,杨巨成. 急性冠脉综合征“络风内动”假说再认识［J］. 中华中医药杂志, 2002, 17(10):8-10.
［3］ Wang X, Lin ZX, Ge JB, et al. Relationship between traditional chiness medicine syndrome type and coronary arteriography of acute coronary syndrome\[J\]. Chin J Integr Med(Engl), 2003, 9(2):116-119.
［4］ 王显,胡大一. 急性冠脉综合征“络风内动”假说临床研究［J］. 中华中医药杂志, 2008, 23(3):204-208.
［5］ 王显,胡大一,杨士伟,等. 冠状动脉斑块形态学与血浆炎症介质的关系初探［J］. 中华内科杂志, 2008, 47(1):27-30.
［6］ 中国中西医结合学会心血管学会.冠心病中医辨证标准［J］. 中西医结合杂志, 1991, 11(5):257.
［7］ 中国中西医结合学会活血化瘀专业委员会. 血瘀证判断标准［J］. 中西医结合杂志， 1987, 7(3):129.
［8］ Fuchs S, Stabile E, Mintz GS, et al. Intravascular ultrasound findings in patients with acute coronary syndromes with and without troponin elevated I level［J］. Am J Cardiol, 2002, 89(6):1111-1113.

备注/Memo

备注/Memo:
收稿日期：2008-1-23.基金项目：北京中医药科技基金项目资助（2002WX） 通讯作者：王显，主任医师，博士（后），主要从事介入心脏病学和中西医结合心脏病学研究Email:WX0515@hotmail.com
更新日期/Last Update: 2009-04-02