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|本期目录/Table of Contents|

脓毒症时心功能损害机制的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
122-123
栏目:
综述
出版日期:
2009-02-28

文章信息/Info

Title:
-
作者:
陈艳明; 王士雯
解放军总医院老年心血管病研究所，北京 100853
Author(s):
-
关键词:
脓毒症; 细胞因子; 内毒素
Keywords:
-
分类号:
R331.31
DOI:
-
文献标识码:
A
摘要:
脓毒症主要是内毒素介导的全身过度炎性反应综合征，本文综述了参与内毒素致病作用的相关分子,如TNF-α、IL-1β、溶酶体的生物学特性及其在脓毒症心功能损害中的作用。
Abstract:
-

参考文献/References

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［2］ Singer M， De Santis V， Vitale D， et al. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation［J］. Lancet, 2004, 364(9433):S45-S48.
［3］ Levy RJ, Vijayasarathy C, Raj NR, et al. Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis［J］. Shock, 2004, 21(2):110-114.
［4］ Jia L,Takahashi M, Morimoto H, et al. Changes in cardiac lipid metabolism during sepsis: the role of very low-density lipoprotein receptors［J］. Cardiovasc Res, 2006, 69(2):545 -555.
［5］ Mink SN, Jacobs H, Bose D, et al. Lysozyme: a mediator of myocardial depression and adrenergic dysfunction in septic shock in dogs［J］. J Mol Cell Cardiol, 2003, 35(3):265-275.
［6］ Tavener SA, Long EM, Robbins SM, et al. Immune cell Toll-like receptor4 is required for cardiac myocyte impairment during endotoxemia［J］. Circ Res, 2004, 95(7):700-707.
［7］ Thomas JA, Haudek SB, Koroglu T, et al. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction［J］. Am J Physiol Heart Circ Physiol, 2003, 285(2):H597-H606.
［8］ Comini L, Boraso A, Bachetti T, et al. Effects od endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes［J］. Pharmacol Res, 2005, 51(5):409-417.
［9］ Hwang TL, Yeh CC. Hemodynamic and hepatic microcirculational changes in endotoxemic rats treated with different NOS inhibitors［J］. Hepatogastroenterology, 2003, 50(49):188-191.
［10］Rossi MA, Santos CS. Sepsis-related microvascular myocardial damage with giant cell inflammation and calcification［J］. Virchows Arch, 2003, 443(1):87-92.

备注/Memo

备注/Memo:
收稿日期：2006-6-1.作者简介：陈艳明，医师，博士Email:chenyanmingabcd0@sina.com
更新日期/Last Update: 2009-04-02