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|本期目录/Table of Contents|

地高辛低血浓度与慢性心力衰竭的疗效

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第2期
页码:
248-250/254
栏目:
临床研究
出版日期:
2009-03-30

文章信息/Info

Title:
Lower serum digoxin concentration and therapeutic effect on chronic heart failure
作者:
赵晓静1; 彭卓1; 屈莉1; 王锦秋2; 李丽君1
西安交通大学第二医院：1.急诊科，2.药理研究室，陕西 西安 710004
Author(s):
ZHAO Xiao-jing;  PENG Zhuo;  QU Li;  WANG Jin-qiu;  LI Li-jun
Department of Emergency, Second Hospital, Medical College, Xian Jiaotong University, Xi’an 710004, Shaanxi，China
关键词:
心力衰竭; 慢性; 地高辛; 血药浓度
Keywords:
heart failure;  chronic;  digoxin;  serum drug concentration
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 探讨中国人地高辛治疗心衰的有效血药浓度。方法 心力衰竭患者口服地高辛0.125～0.25 mg/d, 3 d后改为0.0625~0.125 mg/d维持，依据服药1周后地高辛血药浓度(SDC)分组，低浓度组（SDC≤0.4 μg/L） 57例，中浓度组（0.4 μg/L
Abstract:
AIM To investigate the effects of lower serum digoxin concentration (SDC, SDC<0.4 μg/L) on heart failure (HF) in Chinese population. METHODS Patients with HF took digoxin: 0.125-0.25 mg daily for three days and then 0.125 mg or 0.0625 mg once a day. All the patients were divided into three groups according to the SDC one week after taking digoxin: the low SDC group (SDC≤0.4 μg/L), middle SDC group (0.4 μg/L0.05). The arrhythmia rate in the high and middle SDC groups was significantly higher than that in the low SDC group (P<0.05). CONCLUSION Mortality rate and arrhythmia rate were higher in high SDC group compared with those in middle and low groups. The low SDC (0.31±0.08) μg/L is safer but as effective as middle and high SDC in HF in chinese population.

参考文献/References

[1］ Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure［J］. N Engl J Med, 2002, 347(18):1403-1411.

［2］ Gerald W, Dorn II, Jeffery D. Manipulating cardiac contractility in heart failure data from mice and men［J］. Circulation, 2004, 109(2):150-158.

［3］ Camerini A, Griffo R, Fabbri G, et al. IN-CHF Investigators. Use of digitalis in the treatment of heart failure: data from the Italian Network on congestive Heart Failure (IN-CHF)［J］. Ital Heart J, 2004, 5(7):523-529.

［4］ Adams KF, Gheorghiade M, Uretsky BF, et al. Clinical benefits of low serum digoxin concentrations in heart failure［J］. J Am Coll Cardiol, 2002, 39(6):946- 953.

［5］ Dec GW. Digoxin remains useful in the management of chronic heart failure［J］. Med Clin North Am, 2003, 87(2):317-337.

［6］ Slatton ML, Irani WN, Hall SA, et al. Does digoxin provide additional hemodynamic and autonomic benefit at higher doses in patients with mild to moderate heart failure and normal sinus rhythm?［J］. J Am Coll Cardiol, 1997, 29(6):1206-1213.

［7］ 张介生,秦耀普,马鑫亮. 实用临床药理［M］ . 北京:中国医药科技出版社, 1993:175-179.

［8］ Ahmed A, Gambassi G, Weaver MT, et al. Effects of discontinuation of digoxin versus continuation at low serum digoxin concentrations in chronic heart failure［J］. Am J Cardiol, 2007, 100(2):280-284.

［9］ 肖翔林,杨新云,陈文瑛,等. 1997-2003年度我院2823例住院病人地高辛血药浓度监测与分析［J］. 海峡药学, 2004, 16(6):122-124.

备注/Memo

备注/Memo:
收稿日期：2008-5-26.通讯作者：李丽君，教授，主要从事心血管危重症的研究Email: lilijun3162003@yahoo.com.cn 作者简介：赵晓静，主治医师，讲师，博士Email:zxj47@yahoo.com.cn
更新日期/Last Update: 2009-04-16