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|本期目录/Table of Contents|

家兔颈总动脉不稳定斑块模型的建立

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第3期
页码:
354-357
栏目:
基础研究
出版日期:
2009-05-15

文章信息/Info

Title:
Experimental study on establishing an unstable atherosclerotic plaque of common carotid artery in rabbits
作者:
于熙滢1; 曹海利2; 于波1
哈尔滨医科大学附属第二医院:1.心内科，2.介入科,黑龙江 哈尔滨 150086
Author(s):
YU Xi-ying1;  CAO Hai-li2;  YU Bo1
1.Department of Cardiology, 2.Department of Invasive Technology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang, China
关键词:
颈总动脉; 不稳定斑块; 球囊; 动脉粥样硬化
Keywords:
common carotid artery;  unstable atherosclerotic plaque;  saccule;  atherosclerosis
分类号:
R543.5
DOI:
-
文献标识码:
A
摘要:
目的 建立家兔颈总动脉斑块模型。方法 选取60只雄性纯种的新西兰大白兔,随机分为3组,即球囊损伤+高脂组、高脂喂养组及普通饲料喂养组,每组20只。喂养12周后，分别给予中国斑点蝰蛇毒和组胺药物触发，诱发斑块破裂及血栓形成。结果 球囊损伤+高脂组存活17只白兔中，有38处病变狭窄程度超过50％，并且脂质核心较大、纤维帽的厚度小于65 μm，故判定以上38处病变为易损斑块。高脂喂养组中的19只白兔仅8处可判定为易损斑块；普通饲料喂养组中未见易损斑块。结论 高脂饮食饲养后,进行颈总动脉球囊拉伤制作兔易损斑块模型是切实可行的方法。
Abstract:
AIM To establish an unstable atherosclerotic plaque model of common carotid artery in rabbits. METHODS Sixty New Zealand white rabbits were equally randomized into 3 groups: rabbits in group 1 (n=20) underwent balloon-induced arterial wall injury and then were given a diet of 1% cholesterol; rabbits in group 2 (n=20) were fed a diet of 1% cholesterol; and rabbits in group 3 (n=20) were fed a regular diet. After a 12 week diet, triggering of plaque disruption and thrombosis was attempted by injection of Chinese Russell’s viper venom (CRVV) and histamine. RESULTS In group 1, the stenosis in 38 lesions out of the 17 surviving rabbits were greater than 50％ with large lipid core and fibrous cap thinner than 65μm, and they were taken as unstable atherosclerotic plaques. In group 2, unstable atherosclerotic plaques were seen in 8 lesions of the 19 rabbits. In group 3, no unstable atherosclerotic plaques were seen. CONCLUSION An experimental animal model of unstable atherosclerotic plaque can be established by combining high lipid diet and balloon injury.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-5-14.通讯作者：于波，主任医师，主要从事OCT检测易损斑块的研究Email:yuxiying2008@yahoo.com.cn 作者简介：于熙滢，主治医师，硕士生Email:xiyingyu@sina.com
更新日期/Last Update: 2009-05-18