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|本期目录/Table of Contents|

聚乳酸/乙醇酸复合bFGF降解支架在心肌血运重建中的应用实验

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第3期
页码:
383-386
栏目:
临床研究
出版日期:
2009-05-15

文章信息/Info

Title:
Experimental studies of degradable PLGA stent with basic fibroblast growth factor in myocardial revascularization
作者:
赵健1; 刘晓程1; 孔祥荣1; 王颖1; 史蓉芳1; 赵晓斌1; 刘天军2; 吕丰2
中国医学科学院中国协和医科大学:1.泰达国际心血管病医院心外科， 天津 300457；2.生物医学工程研究所分子设计实验室，天津 300193
Author(s):
ZHAO Jian1;  LIU Xiao-cheng1;  KONG Xiang-rong1;  WANG Ying1;  SHI Rong-fang1;  ZHAO Xiao-bin1;  LIU Tian-jun2; LV Feng2
1.Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, 2.Molecular Design Labtory, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300193, China
关键词:
心肌梗死;  缓释; 生长因子; 量化分析
Keywords:
myocardial infarction;  growth factor;  slow release;  quantitative analysis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨高分子缓释降解材料聚乳酸/乙醇酸（poly D,L-lactic/glycolic acid，PLGA）联合碱性成纤维细胞生长因子（basic fibroblast growth factor,bFGF），对心肌缺血区域灌注改善的情况。方法 成功建立小型猪急性心肌梗死模型后随机分至空白对照组、PLGA支架对照组和PLGA复合bFGF支架组；6周后，SPECT结合软件Emory Cardiac Toolbox分析灌注缺损区域质量百分率的变化，超声学指标 LVEDD、LVEDS、FS%评价心脏功能，Image Pro Plus软件量化各组新生血管密度。结果 6周后PLGA复合bFGF支架组新生血管密度、心肌灌注质量缺损百分率与空白对照组、PLGA支架对照组有显著差异（P<0.01），PLGA复合bFGF支架组FS%较空白对照组、PLGA支架对照组显著改善（P<0.05）。结论 bFGF联合PLGA缓释材料能够显著增加新生血管密度，改善缺血部位心肌血流灌注，进而提高心脏功能。
Abstract:
AIM To investigate the effects of degradable poly D, L-lactic/glycolic acid (PLGA) with basic fibroblast growth factor (bFGF) on promoting myocardial revascularization. METHODS Miniswines with acute myocardial infarction were randomly assigned to control group, blank PLGA stent group and PLGA stent with bFGF group. Six weeks postoperatively, quantitative analysis of new vessels was performed by Image Pro Plus software. The mass defect percent of myocardial perfusion was calculated by Emory Cardiac Toolbox software. LVEDd, LVEDs and FS% reflective of cardiac function were measured by echocardiology. RESULTS Six weeks postoperatively, both new vessels density and mass defect percent in PLGA stent with bFGF group showed significant difference compared with those in control group and blank PLGA stent group (P<0.01). FS% in PLGA stent with bFGF group was significantly enhanced compared with that in the other two groups (P<0.05). CONCLUSION bFGF combined with degradable PLGA stent increases new vessel’s density, improves myocardial perfusion and enhances cardiac function.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-8-28.基金项目：天津市科技发展计划项目资助（05YFGZSF02900） 通讯作者：刘晓程，教授，主任医师，主要从事冠心病心肌血运重建的研究Email：liuxc1949@hotmail.com 作者简介：赵健，主治医师，博士Email:doctorzhao66@126.com
更新日期/Last Update: 2009-05-18